GORDON CONF ON MUSCLE EXCITATION/CONTRACTION COUPLING

描述(来自应用程序)： 这是一项帮助资助肌肉会议的提案： 激励-收缩(EC)耦合，定于1997年6月8日至12日，在 科尔比·索耶学院，新汉普郡，由戈登赞助 研究会议。EC耦合，即转换操作的过程 肌肉细胞中增加[Ca~(2+)]i和收缩的潜力是 第一个公认的钙离子信号传递的例子。最新进展，使用多种 技术，强调所涉及的机制和分子的共性 在骨骼肌、心肌和平滑肌以及其他组织中的钙信号传导 细胞的类型，可兴奋的和不可兴奋的。新上市的染料和 共聚焦显微镜方法已经证明了局部 [Ca~(2+)]在肌肉功能测定和控制中的梯度， 神经元和非兴奋性细胞。将这些研究的交汇点带入 考虑到，本次会议的计划是扩大 传统关注骨骼肌，并汇聚钙离子方面的专家 在其他组织中发出信号。 会议将包括九个口头陈述环节，外加 不断地展示海报。第一次会议将制定 信号细胞器的结构和分子组成。以下是 两人将讨论决定离子动态平衡的过程，包括正常情况下 膜通道和泵ATPase的发生以及 决定肌肉疲劳的动态平衡。观察到的变化 有基因传播突变的患者将从 疾病的立场，并作为了解正常角色和 结构-功能关系。EC偶联的主要分子， 电压传感器和钙离子释放通道，将是三个主题 会议，讨论结构-功能关系的研究，调制 由离子、有机配体和其他蛋白质以及它们之间的相互作用 传感器和通道。它们的相互作用及其在细胞内的作用 级别将在第7次会议上讨论。第8次会议将比较最近 测定钙离子释放的基本事件(火花和 相关信号)，最后一次会议将考虑多样性、关系 两类主要发布渠道之间的差异，以及它们的原因 共存。 戈登关于肌肉的会议：EC联结每年定期举行一次 三年，几十年。上一次会议是在1994年7月。这个 会议一直是讨论和讨论的唯一论坛 传播这一领域的进展。它有一个被证明的记录 将来自世界各地的活跃调查人员聚集在一起，以一种形式 这鼓励了思想和未公布数据的自由交流。它的组织 委员会有来自五大洲的代表，并将努力保持 1997年的出席率在地域和世代方面都很均衡 开会。

DESCRIPTION (from the application): This is a proposal to help fund a Conference on Muscle: Excitation-Contraction (EC) Coupling, scheduled for June 8-12, 1997, at Colby Sawyer College, New Hampshire, under the sponsorship of Gordon Research Conferences. EC coupling, the process that translates the action potential in a muscle cell to increase in [Ca2+]i and contraction, is the first recognized example of Ca2+ signalling. Recent advances, using diverse techniques, underscore the commonality of mechanisms and molecules involved in Ca2+ signalling in skeletal, cardiac and smooth muscle, as well as other types of cells, excitable and nonexcitable. Newly available dyes and confocal microscopic approaches have demonstrated the importance of local [Ca2+] gradients in the determination and control of function in muscle, neurons and non excitable cells. Taking this confluence of studies into consideration, the present meeting has been planned to broaden the traditional focus on skeletal muscle, and bring together experts on Ca2+ signalling in other tissues. The conference will consist of nine oral presentation sessions, plus continuous showing of posters. The first session will develop the structural and molecular makeup of the signalling organelles. The following two will discuss processes determining ion homeostasis, including normally occurring membrane channels and pump ATPases, as well as the alterations in homeostasis that determine muscle fatigue. The alterations observed in patients with genetically transmitted mutations will be discussed from the standpoint of disease, and as tools to understand normal roles and structure-function relationships. The main molecules of EC coupling, the voltage sensor and the Ca2+ release channel, will be the topic of three sessions, discussing studies of structure-function relationship, modulation by ions, organic ligands and other proteins, and interactions between sensors and channels. Their interaction and the function at the cellular level will be considered in session 7. Session 8 will compare recent advances in determination of elementary events of Ca2+ release (sparks and related signals) and a final session will consider diversity, relationships between the two main classes of release channels, and reasons for their coexistence. The Gordon Conference on Muscle: EC coupling has been held regularly every three years for several decades. The last meeting was in July, 1994. The conference has consistently been the sole forum for discussion and dissemination of the advances in this field. It has a proven record of bringing together active investigators from all over the world, in a format that encourages free exchange of ideas and unpublished data. Its organizing committee has representatives from five continents, and will strive to keep a well balanced attendance, geographically and generationally, for its 1997 meeting.