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描述(来自应用程序)： 此应用程序用于支持戈登研究会议(GRC) 伤口修复，将于1997年6月8日至13日举行。这将是第三届GRC 在这个话题上。第一届GRC(1993)有95人参加；第二届(1995)有 超过100人；1997年会议的出席人数应接近135人的限制。 伤口修复是一种基本的、复杂的生物现象，对 寄主生存。阐明伤口愈合的机制 对胚胎发生、血管发生、 炎症、纤维化和实体肿瘤的发展。创面的领域 维修已经经历了现代化的爆炸性阶段，面对 在细胞-细胞和细胞-基质相互作用领域的最新发现， 以及细胞因子/生长因子及其信号转导方式。这个 通过开发控制异常伤口修复的可能性 这些基本的进展，包括基因治疗的可能性，现在是 显然，这是一个现实。虽然有许多论坛聚集在一起 针对创伤修复领域的主题，GRC提供了独特的 为交流最先进的信息而营造的亲密氛围。这个 1997年会议将处理炎症反应的各个方面， 炎症细胞与血小板相互作用机制的研究进展 在凝血过程中与纤维蛋白原/纤维蛋白结合。的作用 细胞因子、生长因子及其受体在细胞调控中的作用 增殖、细胞外基质(ECM)沉积和血管生成 被讨论过了。上皮细胞之间相互作用的作用， 将介绍修复过程中的间充质和细胞外基质，以及耐人寻味的 胎儿伤口愈合过程的生物学及干细胞的性质和作用 正在修复的细胞将得到解决。最后，将有一场会议 考虑内毒素在激活宿主防御机制中的作用。 显然，了解修复涉及的机制，并阐明 复杂的分子和细胞相互作用的本质 伤口的放置将产生深远的影响。GRC提出了一项 促进关于伤口修复生物学的讨论的重要论坛， 正是为了这个目的，我们寻求支持。

DESCRIPTION (from the application): This application is for support for a Gordon Research Conference (GRC) on Wound Repair, to be held from June 8-13, 1997. This will be the third GRC on this topic. The first GRC (1993) had 95 attendees; the second (1995) had over 100; the 1997 conference should approach the attendance limit of 135. Wound repair is a fundamental, complex biological phenomenon essential to host survival. Elucidation of the mechanisms by which wounds heal provides insights into such diverse processes as embryogenesis, vasculogenesis, inflammation, fibrosis, and solid tumor development. The field of wound repair has undergone an explosive phase of modernization in the face of recent discoveries in the areas of cell-cell and cell-matrix interactions, and of cytokines/growth factors and their mode of signal transduction. The possibilities of controlling aberrant wound repair through the exploitation of these basic advances, including the potential for gene therapy, is now clearly a reality. While there are a number of forums that convene to address topics in the wound repair field, the GRC provides a unique and intimate atmosphere for the exchange of state-of-the-art information. The 1997 conference will deal with aspects of the inflammatory response, and the mechanisms involved in the interactions of inflammatory cells and platelets with fibrinogen/fibrin in the blood coagulation process. The role of cytokines and growth factors and their receptors in controlling cell proliferation, extracellular matrix (ECM) deposition and angiogenesis will be discussed. The role of the interactions between epithelial cells, mesenchyme and ECM in repair processes will be addressed, and the intriguing biology of the fetal wound healing process and the nature and role of stem cells in repair will be addressed. Finally, there will be a session considering the role of endotoxin in activating host defense mechanisms. Clearly, understanding the mechanisms involved in repair, and elucidating the nature of the complex molecular and cellular interactions that take place in wounds will have far reaching implications. The GRC presents an important forum for stimulating discussion on the biology of wound repair, and it is to this end that we seek support.