US/JAPAN SEMINAR--BIOSYNTHESIS OF NATURAL PRODUCTS

描述(申请者描述)第五届美日研讨会 民族产品的生物合成将由教授共同组织 Heinz G.Flos，华盛顿大学西雅图分校，Rodney B.Croteau和 诺曼·G·刘易斯，华盛顿州立大学普尔曼分校，美国 东京大学的Ebizuka Yutaka教授和东京的Kakinuma胜美教授 日本理工学院。将于1997年6月15日至20日在Sun举行 位于华盛顿州温斯罗普的Mountain Lodge，它将把 主要是来自这两个县的学术参与者和观察员 来自加拿大的几位主要研究人员和来自加拿大的两位特邀演讲者 欧洲。除了知名的参与者外，还计划 邀请几位初级科学家和新手到这个领域来。这些将是 从核心参与者提名的候选人中挑选。一个 一些工业研究人员也将被邀请，以提供 基础科学与实际应用之间的重要联系 从它那里。课程表将包括上午和晚上的讲座， 下午有充足的时间进行非正式的互动 与会者激发创造性的思想交流。壮观 自上一次研讨会以来，生物合成研究取得了进展 1994年出版，并有新的发展方向，特别是在翻译方面 掌握天然产物生物合成方面的基础知识 在产生新的有用分子或商业上的应用 通过生物工艺生产具有重要经济价值的化合物。这个 海洋天然产物生物合成和生物合成实验工作的出现 对天然产品的生态作用的认识日益增强 生物合成是其他值得注意的发展。其中许多进展将 成为第五届美日双年展演讲和讨论的主题 以“面向工程生物化学”为中心的研讨会 自然产品结构和功能的多样性对 多年来，为药物发现提供了源泉， 目前使用的临床药物中有一部分是天然产品或 从天然产品中提取的铅。该计划的一个主要目标是 会议的目的是评估目前对生物合成途径和 它们多样性的分子起源，并探索这种知识如何 在发现“组合生物化学”中的应用 和/或生产新药。这是一个很高的主题 NIH的许多研究所，特别是国家癌症研究所的兴趣 该研究所最近在一个特别讲习班上探讨了这些问题。

DESCRIPTION (Applicant's Description) The 5th U.S.-Japan Seminar on the Biosynthesis of National Products will be jointly organized by Professors Heinz G. Floss, University of Washington, Seattle, Rodney B. Croteau and Norman G. Lewis, Washington State University, Pullman, in the US, and Professors Yutaka Ebizuka, Universiy of Tokyo, and Katsumi Kakinuma, Tokyo Insitute of Technology, in Japan. To be held on June 15-20, 1997 at Sun Mountain Lodge in Winthrop, State of Washington, it will bring together primarily academic participants and observers from the two counties, as well as a few leading researchers from Canada and two invited speakers from Europe. In addition to the well-established participants, it is planned to invite several junior scientists and newcomers to the field. These will be selected from a pool of candidates nominated by the core participants. A number of industrial researchers will also be invited, to provide an important link between basic science and practical applications emanating from it. The schedule will feature lectures in the morning and evening, with ample time in the afternoon for informal interactions between the participants to stimulate the creative exchange of ideas. Spectacular advances have been made in biosynthetic research since the last Seminar in 1994, and new directions are developing, especially in the translation of basic knowledge in the field of natural products biosynthesis into potential applications in the generation of new useful molecules or the commerical production of economically important compounds by bioprocesses. The emergence of experimental work in marine natural products biosynthesis and an increasing awareness of the ecological role of natural product biosythesis are other noteworthy developments. Many of these advances will be the subject of lectures and discussions at the 5th U.S.-Japan Binational Seminar, with its focus directed "Towards Engineering Biochemical Diversity". Diversity in natural product structure and function has, for many years, provided the wellspring of pharmaceutical discovery, a large fraction of the currently used clinical drugs being natural products or having been derived from natural products leads. A major objective of the meeting is to assess the current knowledge of biosynthetic pathways and the molecular origins of their diversity, and to explore how this knowledge can be utilized in applications of "combinatorial biochemistry" to the discovery and/or production of new pharmaceuticals. This is a subject of high interest to many institutes of the NIH, particularly the National Cancer Institute, which recently explored these issues in a special workshop.