CONFERENCE ON HEMATOPOIESIS

描述(申请人的描述)目前最令人兴奋的研究 造血涉及干细胞分离、鉴定和临床。 应用，以及造血激素的分子生理学。 造血激素及其受体、受体拮抗剂和可溶性 受体在宿主防御中起着至关重要的作用，并在临床上的应用 治疗已成为当今最重要的生物学和临床课题之一。 在过去二十年里。最近的重要进展包括分离出 血小板生成素与新的造血药的发现和应用 荷尔蒙和宿主防御调节剂。我们对干细胞的理解 生理学仍处于初级阶段，但造血干细胞发挥着 在肿瘤疾病的新的和创造性治疗中的核心作用以及 用于遗传性和某些获得性疾病的基因治疗。这个 正常组织和肿瘤组织中促红细胞生成素信号通路的特征 细胞和治疗干预的新靶点的定义是 关键问题。会议的目标将是解决主要的 上面概述的关于正常和肿瘤造血和 主场防守。总体目标是综合专业信息 并定义了该领域的最新水平。该节目将带来 将世界专家与指定的议程聚集在一起，并建立互动的 为知名科学家、研究生和博士后提供的环境 伙计们。

DESCRIPTION (Applicant's Description) The most exciting current research in hematopoiesis involves stem cell isolation, characterization, and clinical application, and the molecular physiology of the hematopoietic hormones. Hematopoietic hormones, their receptors, receptor antagonists, and soluble receptors play a crucial role in host defense, and their use in clinical therapy has become one of the most important biologic and clinical topics of the last two decades. Important recent advances include the isolation of thrombopoietin and the discovery and application of new hematopoietic hormones and host defense modulatotors. Our understanding of stem cell physiology is still rudimentary but the hematopoietic stem cell plays a central role in new and creative therapies for neoplastic disease as well as for gene therapy of genetic and certain acquired disorders. The characterization of hemopoietin-signaling pathways in normal and neoplastic cells and the definition of new targets for therapeutic intervention are critical issues. The goal of the conference will be to address the major questions outlined above regarding normal and neoplastic hematopoiesis and host defense. The overall aim is to synthesize the specialized information and define the state of the art in the field. The program will bring together world experts with an assigned agenda and establish an interactive environment for established scientists, graduate students, and postdoctoral fellows.