CONFERENCE ON LIPID MEDIATORS

描述（改编自申请人的摘要）：请求支持 涵盖分子生物学最新进展的多学科会议， 脂质介质的调节和药理学将在Keystone举行， 科罗拉多，1997年1月24-30日。 脂质介质是一个多样化的家族， 分子越来越被认为在正常的 生理学和病理生理学。 研究进展 调节前列腺素、白三烯、血栓烷 和血小板活化因子已经揭示了意想不到的多种机制， 包括PGH合酶新基因的表达， 核被膜在白三烯生物合成中的作用，以及PAF的重要性 乙酰水解酶调节炎症。 此外，非酶 已经发现基于自由基生物化学的机制产生 类二十烷酸异构分子（类胡萝卜素和白三烯） 其具有有效的生物学活性并作为脂质的新标记物 过氧化作用 还发现新的氧化磷脂 PAF受体激动剂。 这次会议的目的是 与参与脂质介质研究的主要研究人员一起， 更好地了解脂质介质的生物合成，调节， 控制可以出现。 在过去的二十年里， 几乎每年，作为一个论坛，调查人员感兴趣的是， eicosanoids交流信息和讨论最新进展。 的 这次会议非正式性质使与会者之间的互动最大化， 包括研究生、博士后研究员、大学调查员 以及制药行业的人。 尽管重大 过去几年取得的进展， 直接或间接参与脂质介质的科学家们一起， 在海外。 这限制了美国许多调查人员的访问 各国，特别是学生和博士后研究员参加。 这次会议有一个主要目标， 进一步发展，并鼓励学生和博士后 参与脂质介质基础研究。

DESCRIPTION (Adapted from Applicant's Abstract): Support is requested for a multidisciplinary conference covering recent advances in molecular biology, regulation, and pharmacology of lipid mediators to be held in Keystone, Colorado, january 24-30, 1997. Lipid mediators are a diverse family of molecules increasingly recognized as playing an important role in normal physiology as well as pathophysiology. Recent advances in studies of the regulation of the synthesis of prostaglandins, leukotrienes, thromboxanes, and platelet activating factor have revealed unexpected diverse mechanisms, including expression of a novel gene for PGH synthase, involvement of the nuclear envelope in leukotrience biosynthesis, and the importance of PAF acetyl hydrolase in regulating inflammation. In addition, nonenzymatic mechanisms based upon free radical biochemistry have been found to generate molecules isomeric to eicosanoids (both prostaglandins and leukotrienes) which have potent biological activity and serve as novel markers of lipid peroxidation. Novel oxidized phospholipids have also been found to be agonists for the PAF receptor. The goal of this meeting is to bring together the leading investigators involved in lipid mediator research so that a better understanding of lipid mediator biosynthesis, regulation, and control can emerge. For the past two decades a Winter Prostaglandin Conference had been held almost every year, serving as a forum for investigators interested in eicosanoids to exchange information and discuss recent advances. The informal nature of this meeting maximized interaction between participants, including graduate students, postdoctoral fellows, university investigators as well as those from the pharmaceutical industry. In spite of significant advances made within the past few years, most of the meetings which bring together scientists directly or indirectly involved in lipid mediators, have been overseas. This has limited access for many investigators in the United States to participate, and in particular students and postdoctoral fellows. This conference has a major goal to reinstitute this meeting, to stimulate further development in this area, and to encourage student and postdoctoral participation in lipid mediator basic research.