CORE--DNA CHEMISTRY FACILITY

DNA化学亚核代表了以前的 DNA/分子生物学设施和新建立的DNA测序 设施。它是细胞和分子生物学服务的关键组成部分 核心。这个亚核为DRTC和其他Vanderbilt提供合成DNA 调查人员并执行自动DNA测序。这两个 实验室已被合并为一个亚核，以避免重复 在这方面，他们将继续努力，并在相互补充的任务之间提供协同增效作用。 40名DRTC研究人员使用了寡核苷酸合成实验室 1994年聚合了大约32000个脱氧核糖核酸碱基。这个 寡核苷酸合成实验室也得到了成员的使用和支持 癌症和生殖生物学中心。总共大约有 为所有用户聚合了59000个碱基。一个监督委员会提供帮助 确保它为DRTC和所有这些调查人员提供良好的服务。这个 DNA测序实验室成立于1994年，与 由DRTC和范德比尔特癌症中心管理。它的用法有 该资源增长迅速，目前已接近产能。两个人 该次核心的实验室在一年中获得了用户的高度认可 提交前对我们的服务设施进行审查。数量的增长 预计会有使用这个亚核的调查人员。

The DNA Chemistry Subcore represents a merger of the previous DNA/Molecular Biology facility and a newly established DNA Sequencing facility. It is a key component of the Cell and Molecular Biology Services Core. This subcore provides synthetic DNA to DRTC and other Vanderbilt investigators and performs automated DNA sequencing. These two laboratories have been combined into a single subcore to avoid duplication of effort and to provide synergy between their complementary missions. The oligonucleotide synthesis laboratory was used by 40 DRTC investigators in 1994 to polymerize approximately 32000 bases of DNA. The oligonucleotide synthesis laboratory is also used and supported by members of the Cancer and Reproductive Biology Centers. A total of approximately 59000 bases were polymerized for all users. An oversight committee helps assure that it serves the DRTC and all of these investigators well. The DNA sequencing laboratory was established in 1994 and is jointly administered by the DRTC and the Vanderbilt Cancer Center. Its usage has grown rapidly and the resource is now operating near capacity. The two laboratories of this subcore met with high user approval in a presubmission review of our service facilities. Growth in the number of investigators who use this subcore is expected.