RESEARCH AND TRAINING FOR BIOMEDICAL CAREER DEVELOPMENT

约克学院MBRS项目的目标--“研究和培训” 促进生物医学职业发展“-是为了改善和加强 研究环境和拓宽生物医学研究的范围 自然科学部门的两个目的：(1)改善 研究技能和提高教师的学术生产力 (2)为少数民族学生提供更多的 获得知识、专业知识和动力的机会 (A)引导他们从事生物医学研究；和(B)使他们能够 成功地竞争研究生院和专业学校的职位。 为此，要求为6个细胞生物学、物理学项目提供支持 化学、分子生物学、微生物和分子遗传学以及有机 化学反应。还要求为将参与的18名学生提供支持 在规划和实施研究的所有阶段，以及 在报告和公布结果方面也是如此。 在项目#1“用于预测人体毒性的体外模型”中 体外细胞培养技术的发展具有预测的潜力 对化学品和药物的急性人体毒性。在项目2中，“电子产品” 简单卟啉和细菌视紫红质的光谱“，激发 我们将研究模型生物发色团的电子态。在……里面 项目#3，“5SRNA加工的序列和结构信号” 将产生突变的RNA并进行分析。 项目4，“人类自发染色体重排的分子基础” 大肠埃希氏菌的hemB基因“，其核苷酸序列 插入、删除和其他像差将被确定并 分析过了。项目5，“环扩展核苷类似物及相关物质” 化合物“将研究抗病毒的立体化学要求 新型核苷类似物的受控合成及其活性 在项目#6“蛋白质核磁共振的唯一标记氨基酸”中，2H、13C和 15N标记的氨基酸将被合成并并入蛋白质中 用于进一步的溶液和固体核磁共振研究。子项目#3是新的 这项MBR提案。所有其他次级项目都是医疗费用减排赠款的组成部分。 目前由约克学院持有。

The objectives of the MBRS program at York College - "Research and Training for Biomedical Career Development" - are to improve and strengthen the research environment and to broaden the scope of biomedical research in the department of Natural Sciences for two purposes: (1) to improve the research skills and increase the scholarly productivity of the faculty in the department, and (2) to provide the minority students with increased opportunities to acquire the knowledge, expertise and motivation that will (a) direct them towards careers in biomedical research and (b) enable them to compete successfully for positions in graduate and professional schools. To these ends support is requested for 6 projects in cell biology, physical chemistry, molecular biology, microbial and molecular genetics and organic chemistry. Support is also requested for 18 students who will participate in all phases of the planning and implementation of the research, as well as in the reporting and publication of the results. In project #1, "In Vitro Model for Prediction of Human Toxicity" an in vitro cell culture technique will be developed with potential to predict acute human toxicity to chemicals and drugs. In project #2, "Electronic Spectroscopy of Simple Porphyrins and Bacteriorhodopsin", excited electronic states of model biological chromophores will be studied. In project #3, "Sequence and Structure Signals for 5SRNA processing in Drosophila melanogaster", mutant RNAs will be produced and analyzed. In project #4, "Molecular Basis of Spontaneous Chromosome Rearrangements in the hemB gene of E. coli", the nucleotide sequences which promote insertions, deletions and other aberrations will be determined and analyzed. Project #5, "Ring Expanded Nucleoside Analogs and Related Compounds", will investigate stereochemical requirements for antiviral activity by the controlled synthesis of new types of nucleoside analogs and in project #6 "Uniquely labelled Amino Acids for Protein NMR", 2H, 13C, and 15N labelled amino acids will be synthesized and incorporated into proteins for further study by solution and solid state NMR. Subproject #3 is new to this MBRS proposal. All other subprojects are components of the MBRS grant currently held by York College.