COMBINED NICOTINIC ACID AND CRCL3 SUPPLEMENTATION ON GLUCOSE/LIPID METABOLISM

这项研究的主要目标是确定 联合补充烟酸和氯化铬对血清的影响 总胆固醇、低密度脂蛋白胆固醇、 低密度脂蛋白胆固醇、甘油三酯与高密度脂蛋白 正常志愿者的脂蛋白胆固醇。主要的假设是 被测试的是小剂量烟酸和三氯化铬联合治疗 将导致血清总水平显著降低 胆固醇。第二个假设是：1)Low与Low联合治疗 剂量的烟酸和CrCl3将导致显著减少 低密度脂蛋白、极低密度脂蛋白胆固醇和甘油三酯，以及高密度脂蛋白胆固醇显著升高；2)合并 使用小剂量烟酸和三氯化铬治疗将导致 糖耐量显著改善，显著降低 空腹血糖和胰岛素水平。3)血脂的变化和 血糖参数在那些不理想的受试者中会更大 膳食铬摄入量。4)存在显著的正相关关系 血、尿铬、烟酸测定与膳食的关系 这些营养素的水平。

The primary objective of this study is to determine the effects of combined nicotinic acid and chromium chloride supplementation on serum levels of total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides and high-density lipoprotein cholesterol in normal volunteers. The primary hypothesis to be tested is that combined therapy with low dose nicotinic acid and CrCl3 will result in a significant reduction in serum levels of total cholesterol. The secondary hypotheses are, 1) combined therapy with low dose nicotinic acid and CrCl3 will result in a significant reduction in LDL-C, VLDL-C, and TG, and a significant increase in HDL-C; 2) combined therapy with low dose nicotinic acid and CrCl3 will result in a significant improvement in glucose tolerance, and a significant reduction in fasting glucose, and insulin levels. 3) The changes in lipid and glucose parameters will be greater in those subjects with suboptimal dietary Cr intakes. 4) There will be significant positive correlation between serum and urinary measurements of chromium and niacin and dietary levels of these nutrients.