MECHANISMS OF RESPIRATORY DYSRHYTHMIA IN SLEEP

多种因素相互作用，影响睡眠中的呼吸输出。这 该提案涉及睡眠中研究较少的三个因素 但它们被假设为对 在这种状态下呼吸节律失常的产生或持续。 这些因素是睡眠期间脑血流量的变化， 睡眠在呼吸后排出的强度上，并存在 振荡性呼吸刺激清醒和睡眠受试者的呼吸刺激。这个 拟议中的实验将调查 慢波和快速眼动睡眠时脑血流灌注的变化 低氧和高碳酸血症的情况，与或 在没有缺氧的情况下会损害呼吸后放电，如果是的话，是否 在这种反应中存在性别差异，以及 否则，持续的呼吸刺激可能会导致阵发性 通风不足。这些研究将在未麻醉的 醒着睡着的山羊。本种是拟议研究的理想物种。 原因如下：(A)其独特的脑血管解剖结构使 连续、动态地测量脑血流量，必要时， 它的控制，这是其他方法不可能的；(B)它证明了 使用局部颈动脉小体的可重复性呼吸后放电 刺激；以及(C)具有良好的电测和通风特性 觉醒、慢波和快速眼动睡眠期间的变化 人类。睡眠呼吸障碍是一种比较常见的疾病。 发病率和死亡率都很高。因为它的发病机制仍然存在 目前尚不清楚，治疗仍不够理想。拟议的研究应该会有所帮助 在对导致呼吸道疾病发生的因素的理解中 睡眠中的节律紊乱。

Multiple factors interact to influence respiratory output in sleep. This proposal deals with three factors which have been less studied in sleep but which are hypothesized to be significant contributors to the generation or perpetuation of respiratory dysrhythmias in this state. These factors are changes in brain blood flow during sleep, the effect of sleep on the strength of respiratory afterdischarge, and the presence of an oscillatory respiratory stimulus in the awake and sleeping subject. The experiments proposed will investigate the respiratory consequences of altering cerebral perfusion during slow wave and REM sleep under conditions of hypoxia and hypercapnia, the possibility that sleep with or without hypoxia impairs respiratory afterdischarge and, if so, whether sexual differences exist in this response, and how oscillations in an otherwise persistent respiratory stimulus may cause episodic hypoventilation. The studies are to be performed in the unanesthetized awake and sleeping goat. This species is ideal for the proposed studies for the following reasons: (a) its unique cerebrovascular anatomy allows continuous, dynamic measurement of brain blood flow and when necessary, its control, which is not possible with other methods; (b) it demonstrates reproducible respiratory afterdischarge using a localized carotid body stimulus; and (c) it has well-characterized electrometric and ventilatory changes during wakefulness, slow wave and REM sleep that are similar to human beings. Sleep-disordered breathing is a relatively common disease with significant morbidity and mortality. Because its pathogenesis remains unclear, therapy remains less than ideal. The proposed studies should help in the understanding of factors that lead to the genesis of respiratory dysrhythmias in sleep.