The development of a hand held, point of care, device by Kanichi Research Services Ltd to measure ammonia in breath as a new approach for the immediate diagnosis,treatment and monitoring of Helicobacter Pylori infection facilitating mass population screen

已经有相当多的研究将呼吸中的化学物质的存在、食欲和疾病或障碍联系起来。研究表明，有30多种疾病存在这种联系。目前的诊断通常依赖于对血液、唾液、尿液和粪便的分析。这对个体来说可能是侵入性的或令人不快的，而且实验室在获得结果方面可能会有重大延误。一种用于快速诊断和管理疾病的手持式呼吸捕获设备具有很高的医疗专业人员和家庭监护的潜力。Kanichi计划开发一种平台技术，使用便携式呼吸采集设备中的电化学传感器来测量呼吸中的化学物质。我们的第一个目标是氨。这是因为我们最初的市场研究表明，氨水平的升高与九种不同的医疗条件有关，因此一种设备可以有多种用途。两个最吸引人的适应症被确定为衡量透析在终末期肾脏疾病和幽门螺杆菌感染诊断中的有效性的护理点。这两个适应症在2013年通过TSM POM项目进行了广泛的研究。结果是，没有建立一个透析应用的需求，但得到了医疗顾问和研究人员的大力支持，以寻求更好的幽门螺杆菌诊断和立即治疗方法。Kanichi已经开发出专利的电化学传感器，其测量水平达到所需的100‘sppb。我们还设计了一个收集呼气中氨的概念，以呈现给传感器。该项目的目的是验证这一概念，并与专门从事气体传感和医疗器械开发和营销的工业合作伙伴合作开发基本工作原型。我们还将完善我们对市场空间的了解，并确定我们的进入战略

There has been a considerable research into chemicals in breath linking their presence, orexcess, with disease or disorders. There are over 30 diseases where research has made thislink. Current diagnosis is often dependent on the analysis of blood, saliva,urine and stools. Itcan beinvasive or unpleasant for the individual, and there can be significant Laboratory delays inobtaining results. A point of care hand held device capturing breath for speedy diagnosis andmanagement of disease has high potential for use by medical professionals and for homemonitoring.Kanichi plans to develop a platform technology measuring chemicals in breath usingelectrochemical sensors housed within a portable breath collection device. Our first target isammonia. This is because our initial market research showed that elevated levels of ammoniahave been associated with nine different medical conditions and as such a device could havemultiple applications. The two most attractive indications were determined to be the point ofcare measurement of the effectiveness of dialysis in end stage renal disease, and in thediagnosis of Helicobacter Pylori infection.These two indications were extensively researched in 2013 through a TSM POM project. Theoutcome was that a need was not established for the dialysis application but that strongsupport was received from Medical consultants and researchers for a better method forHelicobacter Pylori diagnosis and immediate treatment.Kanichi has developed patented electrochemical sensors which measure at the required 100'sppb level. We have also designed a concept for collection of the ammonia in breath forpresentation to the sensor. The purpose of this project is to prove this concept and develop abasic working prototype in collaboration with an industrial partners specialising in gas sensingand medical device development and marketing. We will also refine our knowledge of themarket space and determine our entry strategy