AIRWAY RESPONSE TO ENVIRONMENTAL TOXINS

描述：（改编自研究者摘要）该项目是 旨在了解人类活动的生化过程， 白细胞输出生物学上有效的脂质介质，白三烯 (LT)C4. LTC4是一种有效的支气管收缩剂， 是造成气道狭窄的主要原因 LTC4转运蛋白 调节LTC4的释放，因此可能调节 这种介质的局部浓度。计划是研究生物化学 生物物理性质和结构功能关系 这种蛋白质。 为了实现这些目标，研究人员建议 分离并克隆LTC4转运蛋白。一些具体 目的是为了实现这一目标，并进一步研究 LTC4在肺功能减弱的发病机制中的作用。

DESCRIPTION: (Adapted from the Investigator's Abstract) This project is aimed at understanding the biochemical processes by which human leukocytes export the biologically potent lipid mediator, leukotriene (LT) C4. LTC4 is a potent bronchoconstrictor, and has been suggested to be a major contributor to airway constriction. The LTC4 transporter regulates the release of LTC4 and hence potentially regulates the local concentration of this mediator.Plans are to study the biochemical and biophysical properties and the structure function relationship of this protein. To achieve these goals, the investigator proposes to isolate and clone the LTC4 transport protein. A number of specific aims are proposed to achieve this goal and to further investigate the role of LTC4 in the pathogenesis of attenuated pulmonary function.