BUPRENORPHINE MAINTENANCE--DOSE SCHEDULE AND TX SETTING

由于迫切需要开发美沙酮的替代品， 阿片类药物依赖的维持治疗，并扩大 以具有成本效益的方式提供和获得服务， 我们提出了一项为期24周的随机试验， 替代丁丙诺啡维持给药策略的疗效 （每日与每周三次）。这项研究在传统的 维持计划，比较每日丁丙诺啡维持剂量 （第1组）和每周三次维持给药（第2组）。评估 无论是没有重大精神病理学的阿片类药物依赖患者， 对酒精、镇静剂或可卡因的依赖， 频繁给药，受试者（N=90）将需要满足严格的 合格性和排除标准，并将按性别分层， 随机分配治疗前的就业状况。辅导 条件将手动指导和仔细监督，以确保 研究方案依从性和治疗完整性 接近。主要结果包括保留在临床试验中， 减少非法类阿片和其他药物使用，减少艾滋病毒感染 风险行为

Because of the critical needs to develop alternatives to methadone for the maintenance treatment of opioid dependence and to expand the availability and accessibility of services in a cost-effective manner, we are proposing a 24-week randomized trial that will assess the clinical efficacy of alternative buprenorphine maintenance dosing strategies (daily versus thrice-weekly). The study conducted in a traditional maintenance program, compares daily buprenorphine maintenance dosing (Group 1) and thrice-weekly maintenance dosing (Group 2). To assess whether opioid dependent patients without major psychopathology or dependence on alcohol, sedatives or cocaine can benefit from less frequent dosing, subjects (N=90) will be required to meet stringent eligibility and exclusion criteria and will be stratified by gender and employment status prior to random assignment to treatment. Counseling conditions will be manual-guided and carefully supervised to insure adherence to the study protocol and the integrity of the treatment approaches. Major outcomes include retention in the clinical trial, reductions in illicit opioid and other drug use, and reductions in HIV risk behavior.