MECHANISMS OF INTERCELLULAR CALCIUM WAVES

描述：细胞间钙波的潜在机制将是 上皮细胞、神经胶质细胞培养和海马区的研究 外植体培养。细胞间钙波可在多种细胞中观察到 类型：它们协调上皮细胞中的纤毛活动，也是 与伤口愈合的早期阶段有关，细胞生长和 分化和机械转导。因为细胞间钙波 也观察到从神经胶质细胞向神经元传递，它们还可能 在信息处理中发挥作用。数学模型将被用来 研究细胞间钙波。初步工作将检查细胞内 振荡和波动，它们构成了细胞间波的基础。在 根据最近的信息，以前在模拟波浪时使用的假设 传播将被修改并应用于神经胶质细胞中的研究波 文化。最后，该模型将被用来确定 细胞内波可以在更大的空间尺度上耦合形成 具有高度组织性的细胞间波，例如传播 平面波阵面和旋转螺旋线。

DESCRIPTION: The mechanisms underlying intercellular calcium waves will be investigated in epithelial and glial cell cultures and in hippocampal explant cultures. Intercellular Ca waves are observed in a variety of cell types: they coordinate ciliary activity in epithelial cells, and are also implicated in early stages of wound healing, cell growth and differentiation, and mechanotransduction. Because intercellular Ca waves have also been observed passing from glial cells to neurons, they may also play a role in information processing. Mathematical models will be used to study intercellular Ca waves. Initial work will examine intracellular oscillation and waves, which form the basis of intercellular waves. In the light of recent information, assumptions previously used in modelling wave propagation will be modified and applied to the study waves in glial cell cultures. Finally, the model will be used to determine mechanisms by which intracellular waves can be coupled on a larger spatial scale to form intercellular waves with a high degree of organization, e.g. propagating plane wave fronts and rotating spirals.