CARDIAC ELECTROPHYSIOLOGIC IMAGING FROM POTENTIAL FIELDS

该项目的长期目标是开展基础研究 旨在提高对正常人心脏电生理学的理解， 以及心脏状态的紊乱，以进一步开发和评估技术 用于从细胞外电位评估心脏电生理学 并促进成功使用的测量方法的转让 临床竞技场的实验研究。 本研究中提出的 应用代表了研究的扩展和新方向 在目前的补助期内完成。 急性实验研究 使用狗的心脏和心电图映射技术， 在五个相互关联的项目中提出，每个项目都有多个目标， 假设 具体目标：1）心搏间的基础研究 周期长度的（空间）差异、其程度和 2）测量、研究和分析相互作用 周期长度不均匀性、激活序列和 复极差异，3）开发和评价一种新的方法， 直接和局部测量电生理参数， 整合局部空间和时间的电描记图（PEG）贴片 信息，并将尝试解剖电气组件的 传播去极化和复极化波，4）评估和 心电图变化范围及特点分析 从心脏到体表的信息传递，特别是当它们相关时 改进非侵入性临床方法，5）开发和 评价用于起搏标测的新技术， 通过降低不确定性、风险和 成本 而前期工作的重点则集中在提高 作为用于评估心脏行为的方法的一部分， 针对识别和评估电生理学变化， 特别是当它们涉及异常或致瘤状态时。 从 科学的角度，合理的工作是要获得的利益 在提高对正常和异常心脏行为的理解方面。 从健康相关性的角度来看， 拟议的工作在于从提高能力中获益， 检测和评估心脏病以及监测治疗 对高危患者的干预。

Long term objectives of this project are to carry out basic research directed at improving understanding of cardiac electrophysiology in normal and perturbed cardiac states, to further develop and evaluate techniques for assessing cardiac electrophysiology from extracellular potential fields, and to facilitate transfer of measurement methods successfully used in experimental studies to the clinical arena. Studies proposed in this application represent extensions of as well as new directions for research accomplished during the current grant period. Acute experimental studies using canine hearts and electrocardiographic mapping techniques are proposed in five interrelated projects, each of which has multiple aims and hypotheses. Specific aims address 1) fundamental study of between-beat (spatial) disparity of cycle length, its extent and potential role in arrhythmogenesis, 2) measurement, study and analysis of the interaction between and dynamics of cycle length inhomogeneity, activation sequence and repolarization disparity, 3) development and evaluation of a new method for directly and locally measuring electrophysiological parameters using patches of electrograms (PEGs) which integrate local spatial and temporal information and will attempt to dissect electrical components of propagating depolarization and repolarization waves, 4) assessment and analysis of the extent and characteristics of electrocardiographic information transfer from heart to body surfaces, particular as they relate to improving noninvasive, clinical methodology, and 5) development and evaluation of new techniques for use in pace mapping to facilitate and improve performance in EP lab procedures by reducing uncertainty, risk, and cost. Whereas emphasis of the preceding work focused on improving methodology for assessing cardiac behavior, the present application is directed toward identifying and assessing electrophysiological changes, particularly as they relate to abnormal or arrhythmogenic states. From a scientific perspective, rationale for the work is the benefit to be gained in terms of improved understanding of normal and abnormal cardiac behavior. From the perspective of health relatedness, the significance of the proposed work lies in benefit to be derived from improved capability to detect and a assess cardiac disease as well as to monitor therapeutic interventions in patients at risk.