PHLEBOTOMY/PLASMAPHERESIS IN NORMAL VOLUNTEERS W/DISORDERS OF LIPID METABOLISM
PHLEBOTOMY/PLASMAPHERESIS IN NORMAL VOLUNTEERS W/DISORDERS OF LIPID METABOLISM
批准号:
2480113
负责人:
金额:
$3.19万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
X ray crystallography apolipoprotein E atherosclerosis blood chemistry blood lipoprotein metabolism cardiovascular disorder epidemiology clinical research disease /disorder proneness /risk family genetics human subject inborn lipid /lipoprotein disorder lipid structure phlebotomy plasmapheresis protein structure receptor
中文摘要
该方案用于获得血浆脂蛋白和载脂蛋白,
支持格拉德斯通研究所的一些研究项目,
心血管疾病 这些项目包括与下列方面有关的调查:
血浆脂蛋白代谢、动脉粥样硬化和神经细胞功能。
目前的项目旨在测试假设,主要
三种蛋白质之间的结构差异(氨基酸序列差异)
载脂蛋白-E的主要亚型解释了不同的三级
影响脂蛋白代谢中同种型功能的结构。
英文摘要
This protocol is used to obtain plasma lipoproteins and apolipoproteins to
support a number of research projects in the Gladstone Institute of
Cardiovascular Disease. The projects include investigations related to
plasma lipoprotein metabolism, atherosclerosis, and neural cell function.
The current project is designed to test the hypothesis that primary
structure differences (amino acid sequence differences) between the three
major isoforms of apolipoprotein-E account for different tertiary
structures that affect isoform function in lipoprotein metabolism.
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