STUDIES OF CANCER IN FAMILIES

佛蒙特州癌症中心的家族性癌症项目是一个 多学科的临床和研究计划，以满足需求 患癌风险过高的患者和家庭。程序 协调高风险干预、筛查方案和研究 包括从高风险患者采集标本的方案 和他们的家人进行基因研究。该计划的重点 是多种多样的，包括所有已知的家族性癌症综合征，以及 家庭或个人可能有明显的过度风险， 符合特定的综合征在1995年1月12日至1996年11月30日期间， 82个新的家庭提到了该方案。大多数的转介 来自肿瘤学家;在所有转诊病例中， 显示，大约25%的人属于最高风险类别， 患有癌症家族综合症这些研究的数据 这表明，在所有接触中，只有三分之一的接触导致对 包括遗传咨询或其他形式干预。两 FCP最常见的综合征是家族性乳腺癌， 卵巢癌和遗传性非息肉病性结肠癌， 几乎占到所有转介的三分之二。有趣的是，只有10% 符合下列标准的个人或家庭： 家族性乳腺癌或结肠癌实际上会一直持续到 接受基因检测和咨询。 在这项研究中，UVM GCRC被用作静脉切开术的部位 在大多数情况下。GCRC服务允许采集血液 样本并转移到机构的分子诊断 实验室，在那里准备样品并进行各种研究 用于进一步分析的协议。 预计将有100名新 将在1996年1月12日至1997年11月30日期间进行移交。GCRC服务 对这项研究方案至关重要， 血液样本，因为许多患者不愿意参加 在这项研究中，如果与研究标本相关的自付费用 将收取。

The Familial Cancer Program of the Vermont Cancer Center is a multidisciplinary clinical and research program that addresses the needs of patients and families with an excess risk for cancer. The program coordinates high-risk intervention, screening protocols, and research protocols that include collection of specimens from high risk patients and their family members for genetic studies. The focus of the program is diverse, including all known familial cancer syndromes, as well as families or individuals who may have apparent excess risk that does not fit a defined syndrome. During the period 12/1/95- 11/30/96 there were 82 new families referred to the program. The majority of the referrals have been from oncologists; among all referrals, triage review of cases revealed that approximately 25% were in the highest risk category meeting a known cancer familial syndrome. Data from these studies indicate that only one-third of all contacts result in follow-up to include genetic counseling or some other form of intervention. The two most common syndromes referred to the FCP are familial breast and ovarian cancer and hereditary nonpolyposis colon cancer, together making up approximately two-thirds of all referrals. Interestingly, only 10% of those individuals or families meeting established criteria for familial breast or colon cancer will actually follow through to the point of recieving genetic testing and counseling. In this research, the UVM GCRC has been used as the site of phlebotomy for a majority of cases. GCRC services allowed collection of the blood specimen and transfer to the Institution's Molecular Diagnostic Laboratory, where samples were prepared and referred to various research protocols for further analysis. It is anticipated that 100 new referrals will occur during the period 12/1/96-11/30/97. GCRC services have been critical to this research protocol by facilitating collection of blood specimens, as many patients have been reluctant to participate in this study if out-of-pocket costs associated with research specimen collection would be incurred.