BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION

旁路血管成形术血运重建调查(BARI)是 1987年在14个主要站点和5颗卫星上依次启动 评价经皮冠状动脉腔内成形术(PTCA)与搭桥术的疗效。 有多支血管病变和严重心绞痛或缺血的患者。1829年 患者参加了2013年的试验，符合条件但未随机 正在对患者进行跟踪。此外，422名患者的样本被认为 根据他们的血管造影，不符合条件的人也被跟踪。全 患者正在接受为期五年的跟踪调查。的主要目标是 这项试验是为了比较两个随机分组的死亡率， 心肌梗死，需要重复手术，再次住院， 功能状态、放射性核素射出分数和生活质量。 波士顿大学医学中心临床站点随机选择了93名患者， 男63例，女30例。139名患者正在登记处接受随访 14名患者在血管造影术排除的情况下接受随访 子群。 而五年成果的结果将是主要的 这项试验的终点，众所周知，冠状动脉事件 持续发生超过5年，特别是在搭桥手术的患者 做手术。为了充分了解这两个因素的影响 血运重建策略对患者远期预后的影响 这项建议的主要目标是为所有BARI提供10年的跟踪 符合条件的患者。为此，我们将使用相同的方法 我们在第一个五年的随访中使用的数据收集。 我们的高协议合规率和后续行动，除了我们的稳定 工作人员将提供高质量的数据，确保获得 关于经皮冠状动脉腔内成形术与 心脏搭桥手术。此外，我们还将继续积极参与 在小组委员会和小组研究中进行和参与研究 包括SEQOL生活质量分研究。巴里的结果将 对未来冠脉的实践有重要的影响 并影响到数十万名 预计将在未来几年内接受这些程序。

The Bypass Angioplasty Revascularization Investigation (BARI) was initiated in 1987 in fourteen primary sites and five satellites in order to evaluate the efficacy of PTCA vs. bypass surgery in the treatment of patients with multivessel disease and severe angina or ischemia. 1829 patients were enrolled in the trial and 2013 eligible but not randomized patients are being followed. In addition a sample of 422 patients deemed ineligible based on their angiograms are also being followed. All patients are being followed for a five year period. The primary goal of the trial is to compare the two randomized groups in terms of mortality, myocardial infarction, need for repeat procedures, re-hospitalization, functional status, radionuclide ejection fraction, and quality of life. The Boston University Medical Center Clinical Site randomized 93 patients, 63 male and 30 female. 139 patients are being followed in the registry and 14 patients are being followed in the angiographically excluded subgroup. While the results of the five year outcome will serve as the primary endpoint of this trial, it is well recognized that coronary events continue to occur beyond 5 years particularly in patients with bypass surgery. In order to fully understand the impact of these two revascularization strategies on the long term outcome of patients it is the primary aim of this proposal to provide 10 year follow-up for all BARI eligible patients. To accomplish this, we will use the same methods of data collection that we have used during the first five year follow-up. Our high protocol compliance rate and follow-up in addition to our stable staff will provide high-quality data that will ensure acquisition of important information concerning the long-term effectiveness of PTCA vs. bypass surgery. In addition, we will continue to actively participate in the study conduct and participation inn subcommittees and substudies including the SEQOL quality of life substudy. The results of BARI will have an important impact on the future practice of coronary revascularization and affect hundreds of thousands of patients who are expected to undergo these procedures in the next few years.