Genes underlying enteric neuron subtype differentiation

该项目旨在使用新的RNA测序技术来识别对区分几种主要肠道神经元亚型至关重要的基因。消化道的正常发育和功能对身体健康至关重要。胃肠功能依赖于肠道神经系统中神经回路的协调活动。该项目将通过创新地使用下一代RNA测序技术来研究肠神经元亚型分化，从而促进澳大利亚在基础发育神经科学领域的知识基础和研究能力。该项目的成果包括从幼稚干细胞中培养出神经元亚型特异性祖细胞，从长远来看，这将对健康产生显著的好处，因为胃肠功能障碍在澳大利亚是一个巨大的健康和经济负担。

This project aims to use new RNA-sequencing technology to identify genes important for differentiation of several major enteric neuron subtypes. Proper development and function of the digestive tract is crucial for good health. Gastrointestinal function relies on the co-ordinated activity of neural circuits in the enteric nervous system. This project will advance Australia's knowledge base and research capabilities in the field basic developmental neuroscience, by innovative use of Next Generation RNA-sequencing technology to investigate enteric neuron subtype differentiation. The project outcomes include the generation of neuron subtype specific progenitors from naïve stem cells, which will in the longer term have significant health benefits, as gastrointestinal dysfunction is a large health and economic burden in Australia.