HHV-6 IN AIDS--MECHANISMS OF CD4 GENE ACTIVATION

描述(改编自申请人的摘要)：调查人员建议 人类疱疹病毒6型与控制CD4的遗传因素相互作用的研究 通过检测：1)哪些遗传元件(启动子、 增强子、抑制子)由HHV-6激活/解除抑制，以及2)哪个HHV-6 基因(S)负责启动cd4基因。这一知识可能 阐明HHV-6的免疫生物学特性及其活性 可能会导致艾滋病毒疾病，而且它也可能有助于更完整的 对基本免疫学问题的理解，如控制 免疫活性细胞的基因表达。

DESCRIPTION (adapted from applicant's abstract): The investigators propose to study the interactions between HHV-6 and genetic elements controlling CD4 gene expression by examining: 1) which genetic elements (promoter, enhancer, silencer) are activated/derepressed by HHV-6, and 2) which HHV-6 gene(s) is(are) responsible for turning on the CD4 gene. This knowledge may shed light on the immunobiological properties of HHV-6 and how its activity may contribute to HIV disease, and it may also contribute to a more complete understanding of fundamental immunological questions such as the control of gene expression of immunocompetent cells.