GENETIC RISK ASSESSMENT COUNSELING FOR BREAST CANCER

描述：（申请人描述）乳房的一级亲属 癌症患者患上癌症的风险增加了2到10倍， 与一般人群中的女性相比。 分子检测可能 很快就能确定哪些一级亲属（FDR）在 遗传风险更高 风险识别应更早触发 筛查和/或初级预防，以最终减少乳腺癌 发病率和死亡率。 然而，没有开发良好的协议， 促进FDR的风险理解，健康保护行为， 心理调适 哪些罗斯福总统可能会选择基因 咨询以及如何最好地实现积极的心理和行为 接受咨询的人的结果尚不清楚。 200例乳腺癌转介FDRs的前瞻性研究 来自华盛顿大学巴纳德癌症中心的患者。 这是通过：（1）基线电话访谈评估 个人风险认知（和潜在原因），心理 乳腺癌筛查的特点和实践，（2） 参与遗传风险评估咨询， 专业遗传咨询师，和（3）一年的随访电话 访谈以评估咨询之间的行为和心理结果 参与者和非参与者。 我们将比较结果，包括 组间差异在那些谁做和不选择参加 通过研究提供的遗传风险评估咨询，以及 心理和行为结果的组内差异， 咨询参与者和非参与者。 该项目将为FDR制定一份咨询协议， 风险人群，预测哪些FDR将参与遗传风险 评估提供咨询时，并确定基线的影响 咨询后结果的特征。 参与选择和 与风险咨询相关的结果，一旦得到更好的理解， 乳腺癌遗传风险评估咨询的新兴领域 通过确定咨询应该如何为具有不同 感知和特征。 这项研究的结果需要 设计一个有效的机制，为需要了解 他们的风险状况和避免乳腺癌死亡的选择。

DESCRIPTION: (Applicant's Description) First-degree relatives of breast cancer victims are at two-to ten-fold increased risk for developing the disease compared to women in the general population. Molecular testing may soon be able to identify which first-degree relatives (FDRs) are at heightened genetic risk. Risk identification should trigger earlier screening and/or primary prevention to ultimately decrease breast cancer morbidity and mortality. However, there are no well developed protocols for promoting FDRs' risk understanding, health-protecting behaviors, and psychological adjustment. Which FDRs' are likely to opt for genetic counseling and how to best achieve positive psychological and behavioral outcomes among those receiving counseling are unknown. A prospective study on a cohort of 200 FDRs referred by breast cancer patients from the Washington University Barnard Cancer Center is proposed. This is accomplished by: (1) baseline telephone interview assessing personal risk perceptions (and underlying reasons), psychological characteristics, and practice of breast cancer screening, (2) opportunity to participate in Genetic Risk Assessment Counseling conducted by a professional genetic counselor, and (3) one-year follow-up telephone interview to assess behavioral and psychological outcomes between counseling participants and nonparticipants. We will compare outcomes including between-group difference in those who do and do not choose to participate in Genetic Risk Assessment Counseling offered through the study, and within-group differences in psychological and behavioral outcomes among counseling participants and nonparticipants. The project will produce a counseling protocol for FDRs, describe this at-risk population, predict which FDRs will participate in Genetic Risk Assessment Counseling when offered, and determine the influence of baseline characteristics on post-counseling outcomes. Participation choices and outcomes associated with risk counseling, once better understood, can guide the emerging field of Genetic Risk Assessment Counseling for breast cancer by determining how counseling should be tailored for FDRs with different perceptions and characteristics. Findings from this study are required to design an effective mechanism for counseling FDRs who need to understand their risk status and options for avoiding breast cancer mortality.