SYNTHESIS OF DELTA-1-TETRAHYDROCANNABINOL-7-OIC ACID

该项目的主要长期目标是综合 δ-L-四氢大麻酚和各种类似物的主要代谢物。 的 待研究的路线使用通过Wittig反应制备的二烯， 衍生自2，3-二卤代丙烯的鏻盐，用于Diels-Alder 反应制备关键的卤乙烯中间体。 该化合物 然后转化成适当的二氢吡喃大麻素骨架 使用三甲基碘代苯，化学，这是发现在一个较早的 主要大麻素的合成。 合成通过以下步骤完成： 通过有机金属试剂使卤乙烯羧化。

The major long-term objective of this project is the synthesis of the major metabolite of delta-l-tetrahydrocannabinol and various analogs. The route to be investigated uses dienes prepared by a Wittig reaction from phosphonium salts derived from 2,3-dihalopropenes for a Diels-Alder reaction to prepare the key vinyl halide intermediate. This compound is then converted into the appropriate dihydropyran cannabinoid skeleton using trimethylailyl iodide, chemistry which was discovered in an earlier synthesis of the primary cannabinoids. The synthesis is completed by carboxylation of the vinyl halide via an organometallic reagent.