FUNCTIONAL PARAMETERS OF AGING

这一提议的基本前提是，正常的 分化程序在成年哺乳动物心肌中的变化 对年龄的反应，以及这些变化有助于与年龄相关 对缺氧和缺血易感性的差异。我们的专业 假设三磷酸腺苷代谢途径的整合 在老化过程中，合成和利用会发生变化，因此， 老年心肌更易发生急性缺氧和缺血损伤。 推论是：(1)这些变化类似于 在慢性缺氧和多种形式的肥大中观察到，(23) 能量储备的减少(CK系统)有助于增加 (3)老年人糖酵解能力的变化 心肌在低氧时调节phi的不同起着重要作用。

The fundamental premise underlying this proposal is that the normal program of differentiation in the adult mammalian myocardium changes in response to age and that these changes contribute to age-related differences in susceptibility to hypoxia and ischemia. Our major hypotheses are that the integration of the metabolic pathways for ATP synthesis and utilization changes during aging and, as a consequence, aged myocardium is more susceptible to acute hypoxic and ischemic injury. Corollary hypotheses are (1) that these changes are similar to those observed in chronic hypoxia and many forms of hypertrophy, (23) that decreased energy reserve (the CK system) contributes to increased susceptibility and (3) that changes in glycolytic capacity of the aged myocardium contribute to differences in pHi regulation during hypoxia.