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PROTEASE INHIBITORS AND LPS INDUCED FEVER

PROTEASE INHIBITORS AND LPS INDUCED FEVER
蛋白酶抑制剂和 LPS 引起的发烧
批准号：
2695509
负责人：
MATTHEW J KLUGER
金额：
$2.0万
依托单位：
LOVELACE RESPIRATORY RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-30 至 2000-09-29
来源：
https://reporter.nih.gov/project-details/2695509
关键词：
acute phase protein alpha 1 antitrypsin body temperature regulation gene targeting genetically modified animals hyperthermia interleukin 1 interleukin 6 laboratory mouse laboratory rat lipopolysaccharides macroglobulins neutralizing antibody protease inhibitor

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中文摘要
翻译
这项建议中的研究重点是急性期 A1-抗胰蛋白酶(AAT)和a2-巨球蛋白(AMG)为阳性 发烧的调节剂。因为这些蛋白质是蛋白水解酶抑制剂， 调查人员假设，他们的行动是通过增加 循环系统中致热细胞因子的浓度和 下丘脑。拟议的研究是为了测试两个潜在的模型。 其具体目的是：1.检验AAT作为一种 内源性热原在脂多糖诱导的发热中的作用；2.检验假设 AMG在脂多糖诱导的发热中起内源性热原的作用；3.检测 假设循环中的AAT和AMG通过 细胞因子清除的调节。
英文摘要
Studies in this proposal focus on the mechanism by which the acute-phase proteins a1-antitrypsin (AAT) and a2-macroglobulin (AMG) act as positive modulators of fever. Because these proteins are protease inhibitors, the investigators hypothesize that they act by increasing the concentrations of pyrogenic cytokines in the circulatory system and the hypothalamus. The proposed studies are to test two potential models. The specific aims are to: 1. Test the hypothesis that AAT acts as an endogenous pyrogen during LPS-induced fever; 2. Test the hypothesis that AMG acts as an endogenous pyrogen during LPS-induced fever; 3. Test the hypothesis that circulating AAT and AMG modulate fever via the regulation of cytokine clearance.
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会议论文
PHYSIOLOGIC ROLE OF CYTOKINES IN LIPOPOLYSACCHARIDE
PSYCHOSOCIAL STRESS-INDUCED FEVER--THE ROLES CYTOKINES
STRESS-INDUCED FEVER -- ROLE OF CYTOKINES AND HORMONES
PSYCHOSOCIAL STRESS-INDUCED FEVER--THE ROLES OF CYTOKINE
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