ANKYLOSING SPONDYLITIS RESEARCH--HLA B27 AND BEYOND

说明(取自应用程序)：请求支持两个 强直性脊柱炎研究：人类白细胞抗原-B27和 Beyond“将于1998年9月1日和2日在美国国立卫生研究院校园举行 贝塞斯达。这次会议目的是汇聚一组基本的 以及来自不同学科的临床科学家进行批判性评估 正在进行的与AS相关的研究，并确定潜在的新途径 对这种疾病的发病机制进行研究。 作为一种比较常见的，慢性的，疼痛的，变形的，炎症性的 风湿性疾病，影响中轴骨骼，在不同程度上， 其他关节和非关节部位，发病年龄中位数为23岁 好几年了。其发病机制尚不清楚，目前的治疗方法 在许多患者中，不能充分防止畸形和残疾。在最近 几十年来，AS的研究一直富有成效地集中在临床上 分类、流行病学和遗传学，而在 潜在的细菌触发物。相对较少的调查 致力于研究这种疾病的细胞和分子发病机制， 特别是关于中轴线骨骼的慢性变化。这个 这次会议的总体目标将是通过以下方式激发研究 为正在进行的研究提供建设性的批评意见，并通过吸引 来自学科的想法和方法，可以有效地应用于 作为研究，但目前还不是。这两种方法都将利用 NIH调查人员的出席。计划举行四次半天的会议： (I)强直性脊柱炎的临床、放射学和遗传学方面；。(Ii)免疫学和 免疫发病机制；(Iii)骨、软骨和结缔组织；(Iv) 炎症性肠病、细菌和粘膜免疫学。会话1 和2目前主要由调查人员的陈述组成 从事研究，这些会议将对 获得基础免疫学家和其他研究人员的批评意见 来自美国国立卫生研究院。第三次和第四次会议将主要由调查人员组成 分别在分子生物学和细胞生物学方面开展工作 细胞外基质，以及对猪的免疫学和微生物学 肠道和炎症性肠病。这些会议也将受益 来自NIH调查人员的参与。会议的形式是 组织最大限度的讨论，促进新的合作，并 吸引现有的和新的研究人员来研究与AS相关的问题。

DESCRIPTION (Taken from the application): Support is requested for a two day conference entitled "Ankylosing Spondylitis Research: HLA-B27 and Beyond," to be held on September 1 and 2, 1998, on the NIH campus in Bethesda. The purpose of this meeting is bring together a group of basic and clinical scientists from a variety of disciplines to critically evaluate ongoing research related to AS and to identify potential new avenues of research into the pathogenesis of this disorder. AS is a relatively common, chronic, painful, deforming, inflammatory rheumatic disease that affects the axial skeleton and, to a variable extent, other articular and nonarticular sites, with the onset at a median age of 23 years. Its pathogenesis is poorly understood, and current therapy inadequately prevents deformity and disability in many patients. In recent decades, investigation of AS has focused productively on clinical classification, epidemiology and genetics, and less productively on potential bacterial triggers. Relatively little investigation has been devoted to the cellular and molecular pathogenesis of the disease, particularly with regard to the chronic changes in the axial skeleton. The overall goal of this conference will be to galvanize AS research by providing constructive critical input for ongoing research and by attracting ideas and methodology from disciplines that could productively be applied to AS research but currently are not. Both approaches will take advantage of the attendance of NIH investigators. Four half day sessions are planned: (i) clinical, radiographic, and genetic aspects of AS; (ii) immunology and immunopathogenesis; (iii) bone, cartilage, and connective tissue; (iv) inflammatory bowel disease, bacteria, and mucosal immunology. Sessions 1 and 2 will consist predominantly of presentations by investigators currently engaged in AS research, and these sessions will be particularly valuable for gaining critical comments from basic immunologists and other investigators from NIH. Sessions 3 and 4 will consist predominantly of investigators working, respectively, on the molecular and cell biology of the extracellular matrix, and on the immunology and microbiology of the intestine and inflammatory bowel disease. These sessions will also benefit from the participation of NIH investigators. The format of the meeting is being organized to maximize discussion, to foster new collaborations, and to attract established and new investigators to work on problems related to AS.