23RD INTERNATIONAL HERPESVIRUS WORKSHOP, YORK, ENGLAND

描述(申请人描述)：本建议书申请资金用于 使年轻研究人员能够参加第23届国际疱疹病毒会议 1998年8月1日至7日在英国约克大学举办的研讨会。这个 国际疱疹病毒研讨会是 疱疹病毒研究人员，以及唯一一次与跨学科 重点关注疱疹病毒的所有主要亚家族和 从分子生物学研究到临床研究。强者的力量 研讨会依赖于交叉受精，这是通过比较 不同的疱疹病毒，解决关键问题的不同方法 该领域领先研究人员的支持和参与，MOST 重要的是，包括有前途的年轻研究人员和学生 训练。此外，该论坛具有真正的国际性，基础广泛。 世界各地的观众。 从广泛的角度来看，这次会议的医学重要性是显而易见的 由现在公认的八种人类疱疹病毒引起的各种疾病。 这些疾病包括皮肤和眼睛溃疡(HSV-1)、生殖器病变(HSV-2)、 脑膜炎和脑炎(HSV-1和HSV-2)、传染性单核细胞增多症 (EBV)、水痘和带状疱疹(VZV)。巨细胞病毒是婴儿出生的主要原因 缺陷包括智力低下、失明和耳聋 先天性传播，但也是一种重要的机会病原体 艾滋病患者和器官移植受者。最近，CMV和HSV 都被认为是疾病发展的致病因素 动脉硬化。癌症也与疱疹病毒有关。 感染。EB病毒与Burkitt淋巴瘤和其他B细胞相关 肿瘤和鼻咽癌。最新的人类疱疹病毒 发现的(HHV-8或KSHV)与艾滋病患者的卡波西肉瘤有关 患者和其他免疫抑制者以及其他组。所有的 疱疹病毒会持续一生，因此会给人类带来严重的问题 对免疫受损的人的治疗。因以下原因引起的疾病 大多数人类疱疹病毒的重新激活是导致 不同免疫患者人群的发病率和死亡率。带状疱疹和 带状疱疹后神经痛是老年人的问题。动物疱疹[有] 对家禽(马立克氏猪和其他)、猪的重要经济意义 (伪狂犬病病毒)、牛(几种牛疱疹病毒)和马 (几种马疱疹病毒)。此外，这些抗病毒疱疹还可以 作为研究疱疹病毒发病机制的重要模型系统。最后， 重组DNA技术使设计新型疫苗成为可能 控制动物传播疱疹病毒感染的设计 疱疹病毒基因治疗载体[原文如此]。 研讨会将对以下内容采取跨学科的方法 主题：病毒结构，病毒入侵机制和细胞间传播， 膜蛋白，发病机制和潜伏期，DNA复制，疫苗接种 以及免疫反应、转录调控、基因调控 表达、化疗靶点和病毒基因治疗。此外, 两场点名讲座将由做出重大贡献的个人进行 对疱疹病毒学知识的贡献。

DESCRIPTION (Applicant's Description): This proposal requests funds to enable young investigators to attend the 23rd International Herpesvirus Workshop at the University of York in York, England, August 1-7, 1998. The International Herpesvirus Workshop is the premier scientific meeting for herpesvirus researchers, and the only meeting with an interdisciplinary focus on all the major subfamilies of herpes viruses and all aspects of research from molecular biology to clinical studies. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpes viruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based worldwide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now recognized eight human herpes viruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but is also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV and HSV have been implicated as pathogenetic contributors in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups. All of the herpes viruses persist for life and therefore pose significant problems in the treatment of immunologically compromised persons. Diseases due to reactivation of most human herpes viruses are a significant cause of morbidity and mortality in various immune patient populations. Shingles and post-herpetic neuralgia are problems in the elderly. Animal herpes [have] significant economic importance to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpes viruses) and horses (several equine herpes viruses). In addition, these antiviral herpes serve as important model systems for studying herpesvirus pathogenesis. Finally, recombinant DNA technology permits the design of novel vaccines for controlling the spread of animal an herpesvirus infect the design of herpesvirus vectors for gene therapy [sic]. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy. In addition, two named lectures will be given by individuals who have made substantial contributions to the knowledge of herpes virology.