MOLECULAR MECHANISMS OF MUSCLE RESPONSES TO EXERCISE

肌肉是由各种不同的肌肉纤维组成， 生物化学、结构和生理特性。的 这些纤维的特性可以响应于多种因素而改变， 刺激，如身体和神经活动，激素变化， 肌肉损伤和肌肉疾病。这种现象的潜在机制 肌肉的可塑性在很大程度上是未知的，但对于 了解肌肉疾病的过程和 锻炼退化和再生。本研究旨在 研究肌肉可塑性的分子机制 由于锻炼。所用的动物模型是脊髓横断 瘫痪/运动大鼠。比目鱼肌和趾长伸肌 将在时间点研究脊髓横断大鼠（T10横断） 运动开始后不久（6小时-5天）， 肌肉特异性转录因子和卫星 细胞参与肌肉的可塑性。具体来说， 确定卫星小区是否被激活，以及激活是否 与肌肉损伤有关。

Muscles are composed of a variety of muscle fibers with different biochemical, structural and physiological properties. The characteristics of these fibers can change in response to a number of stimuli, such as physical and neuronal activity, hormonal changes, muscle damage and muscle diseases. The underlying mechanisms of this muscle plasticity are largely unknown, but are important for understanding processes involved in muscle diseases and the effects of exercise on degeneration and regeneration. The purpose of this study is to investigate the molecular mechanisms underlying muscle plasticity due to exercise. The animal model used is the spinal cord transected paralyzed/exercised rat. Soleus and extensor digitorum longus muscles from spinal transected rats (T10 transection) will be studied at time points shortly (6 hr - 5 days) after the onset of exercise to address the hypothesis that muscle specific transcription factors and satellite cells are involved in muscle plasticity. Specifically, it will be determined if satellite cells are activated and if activation is correlated with muscle damage.