ETHANOL AND PENTOBARBITAL SELF ADMINISTRATION IN RATS

乙醇经常与其他药物共同滥用，因此研究 检查乙醇与其他药物联合使用的自我管理 药物可能有助于开发动物模型， 行为和药物治疗的有效性， 减少多药滥用者的酒精饮用量。 这项建议是 包括三项相关研究。 每项研究都旨在评估 单独使用乙醇的增强效果的一个单独方面是， 以及乙醇与另一种滥用药物的结合。上 将训练研究大鼠口服自我施用以下组合 乙醇和戊巴比妥之后， 将评估乙醇和药物混合物。 这将是 通过检查一个相对的强化效果来完成 与乙醇相比，乙醇/戊巴比妥组合的数量 在一定范围内单独使用并发自我管理程序 固定比率值。 该系列的第二份研究报告提出， 检查纳洛酮对乙醇自我给药的影响 和乙醇加戊巴比妥的混合物。 本研究将使用 乙醇和乙醇加戊巴比妥的新的多重方案 自我给药，以连续评估纳洛酮对 在一次测试中对乙醇和混合物都有反应 上网时段 第三项研究将使用乙醇褪色程序， 尝试训练大鼠口服自我给药戊巴比妥。 如果 成功的话，这种训练程序可能会有效地诱导 大鼠口服自我管理的其他药物滥用以及。 是 我希望这些研究能对人类的行为产生深刻的见解， 和乙醇和多药自身的神经化学参数 局

Ethanol is frequently co-abused with other drugs, therefore studies examining self-administration of ethanol in combination with other drugs may help develop animal models which can assess the efficacy of behavioral and pharmacological treatments designed to reduce ethanol drinking in polydrug abusers. This proposal is comprised of three related studies. Each study is designed to asses an individual aspect of the reinforcing effects of ethanol alone as well as ethanol combined with another drug of abuse. In the first study rats will be trained to orally self-administer a combination of ethanol and pentobarbital after which the reinforcing properties of ethanol and the drug mixture will be assessed. This will be accomplished by examining the relative reinforcing effects of a number of ethanol/pentobarbital combinations compared to ethanol alone using concurrent self-administration procedures over a range of fixed-ratio values. The second study in the series proposes to examine the effects of naltrexone on self-administration of ethanol and an ethanol plus pentobarbital mixture. This study will use a novel multiple schedule of ethanol and ethanol plus pentobarbital self-administration to sequentially assess the effects of naltrexone on responding for both ethanol and the mixture within a single test session. The third study will use an ethanol fading procedure to attempt to train rats to orally self-administer pentobarbital. If successful, this training procedure may prove effective at inducing rats to orally self-administer other drugs of abuse as well. It is hoped that these studies will produce insights into the behavioral and neurochemical parameters of ethanol and polydrug self- administration.