TOURETTES DISORDER IN CHILDREN--PROSPECTIVE FOLLOWUP

描述（改编自申请人的摘要）：这是一个应用程序， 指导临床科学家发展奖（K 08）。 申请人是 成功的临床医生将职业重点从临床工作和医疗 教育到临床研究。 申请人的主要目标是追求 临床研究的职业生涯，专注于临床驱动的问题 实践 在过去的两年里，作为新成立的 马萨诸塞州联合总医院-麦克莱恩儿科医院 精神药理学项目，Joseph Biederman博士，主任，申请人 越来越多地参与临床驱动的项目研究， 专注于妥瑞氏症 然而，缺乏正式的研究 用于研究活动的培训和时间一直很重要 实现独立目标的快速进展的障碍 调查员 通过允许申请人的时间完全集中在 获得必要的工具，成为一个独立的调查员，这 奖励将允许申请人实现这些目标。 在获奖期间，申请人将全面发展 临床研究方法学技能，特别关注纵向 前瞻性研究 这将涉及以下领域的培训： 1)接触临床研究（10%的努力），包括儿科 精神药理学、遗传学、流行病学、纵向随访研究 关于儿科精神药理学方案和多动症的纵向研究 和相关疾病。 此外，她还将继续与 Jenike博士的抽动秽语障碍比较现象学小组 强迫症和神经影像学 2)正式教学 培训（20%的努力）这部分培训将允许 申请人继续接受研究方法学方面的教育， 技术. 这将包括课程工作（详细如下）和教程， 哈佛公共卫生学院生物统计学和流行病学。 （十） 申请人将由主席Nan Laird博士指导。 哈佛公共卫生学院生物统计系， 纵向设计的统计方法（10%的努力）。 第三章 接触一个既定的国家TS研究计划（5%的努力）： 申请人将每月与James Leckman博士（教授）会面。 精神病学）和大卫保罗（遗传学副教授）在耶鲁大学 儿童研究中心对TS的方法，包括发展 精神病理学、临床评估和家庭研究。 4)暴露于 基础神经科学（5%的努力）：申请人将每月与 安妮·杨医学博士哲学博士、马萨诸塞州神经病学服务中心主席 一位国际知名的神经科学家， 长期以来对运动障碍和图雷特氏症的兴趣， 复习与妥瑞氏症有关的基本神经科学问题。 5)的 候选人的指导研究（40%的努力） 提出了一项研究，旨在系统的特征化和类型学的150 患有妥瑞氏症的儿童和青少年， 预计将持续四年。 50名年龄、性别和 SES匹配的非抽动精神病对照将进行评估， 在同一时期跟进。 这项研究将受到监督和指导 Biederman博士。

DESCRIPTION (Adapted from applicant's abstract): This is an application for a Mentored Clinical Scientist Development Award (K08). The Applicant is an accomplished clinician shifting career focus from clinical work and medical education to clinical research. The applicant's primary goal is to pursue a career in clinical research focusing on questions driven by clinical practice. Over the last two years, as a staff member of the newly formed Joint Massachusetts General Hospitals-McLean Hospital Pediatric Psychopharmacology Program, Dr. Joseph Biederman, Director, the applicant has become increasingly involved in clinically-driven, programmatic research focused on Tourette's Disorder. However, the absence of formal research training and time to devote to research activities have been serious impediments for rapid progress toward the goal of becoming an independent investigator. By permitting the full focus of the applicant's time on achieving the necessary tools to become an independent investigator, this Award will allow the applicant to achieve these goals. During the period of the Award the applicant will develop comprehensive skills in clinical research methodology with a special focus on longitudinal pros-pective studies. This will involve training in the following areas: 1) Exposure to Clinical Research (10 percent effort) including pediatric psychopharmacology, genetics, epidemiology, longitudinal follow-up studies on pediatric psychopharmacology protocols and longitudinal studies of ADHD and related disorders. In addition, she will continue her work with Dr.Jenike's group on the comparative phenomenology of Tourette's Disorder and Obsessive-Compulsive Disorder and neuroimaging. 2) Formal Didactic Training (20 percent effort) This part of the training will allow the applicant to pursue further education in research methodology and techniques. This will include course-work (detailed below) and tutorials at the Harvard School of Public Health in biostatistics and epidemiology. (10 percent effort) The applicant will be tutored by Dr. Nan Laird, Chairman of the Department of Biostatistics at the Harvard School of Public Health, on statistical methods of longitudinal designs (10 percent effort). 3) Exposure to an Established National TS Research Program (5 percent effort): The applicant will meet monthly with Drs. James Leckman (Professor of Psychiatry) and David Pauls (Associate Professor of Genetics) at the Yale Child Study Center on methodologic approaches to TS, including developmental psychopathology, clinical assess-ment, and family studies. 4) Exposure to Basic Neuroscience (5 percent effort): The applicant will meet monthly with Anne Young, M.D., Ph.D., Chairman of the Neurology Service at Massachusetts General Hospital, and an internationally known neuroscientist with longstanding interest in movement disorders and Tourette's Disorder, to review basic neuroscience issues related to Tourette's Disorder. 5) The Candidate's Mentored Research Study (40 percent effort) The applicant proposes a study aimed at systematic character-ization and typology of 150 children and adolescents with Tourette's disorder who will then be followed prospectively over four years. A comparison sample of 50 age, gender and SES matched non-tic psychiatric controls will be assessed and systematically followed over the same period. This study will be supervised and mentored by Dr. Biederman.