COMPLIANCE CHAMBERS FOR ARTIFICIAL HEART IMPLANTS

描述(改编自申请人的摘要)：胸腔内 顺应室(ICC)是解决这一问题最成功的方法 全植入搏动性人工心脏的体积问题。 然而，现有的设计受到气体排放速度的影响 穿透腔壁，因为所有的聚合物膜都是 受到一定程度的气体渗透的影响。考虑到这一限制， 经皮充气将需要频繁的间隔时间，测量 几周后。申请者的假设是，这一限制可以是 通过使用液晶聚合物(LCP)进行补救，这是一种材料类别 显著的机械性能，高度的化学惰性，以及极高的 低透气性(本质上相当于玻璃)。申请者 建议开发制造的材料和工艺 极大地改进了ICC。 申请者计划证明LCP具有生物兼容性， 低渗透性、高抗疲劳性和足够的 可制造性是脑室辅助系统的理想候选者 人工心脏顺应室。 建议的商业应用：不可用

DESCRIPTION (Adapted from applicant's abstract): The intrathoracic compliance chamber (ICC) is the most successful solution to the variable volume problem of a totally implanted pulsatile artificial heart. However, existing designs are compromised by the rate at which gas permeates through he chamber walls, given that all polymeric membranes are subject to some degree of gas permeation. Given this limitation, percutaneous gas refills would be required at frequent intervals, measured in weeks. It is the applicants' hypothesis that this limitation can be remedied by the use of liquid crystal polymers (LCPs), a material class of remarkable mechanical properties, high chemical inertness, and extremely low permeability (essentially equivalent to glass). The applicants proposes to develop the materials and processes for the fabrication of vastly improved ICCs. The applicants plan to demonstrate that LCPs have the biocompatibility, low permeability, high fatigue resistance, and sufficient manufacturability to be ideal candidates for ventricular assist system and artificial heart compliance chambers. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE