CHRONIC TELEMETRY OF INTRACRANIAL PRESSURE

在脑肿胀的治疗中，脑灌注压（CPP）是一种有效的治疗方法。 临界参数定义为平均动脉血 颅内压（ICP）。而平均动脉血 压力可以被常规地监测，是一种安全、准确、便宜， 需要可靠的、小型的、可植入的压力遥测装置， 定期监测ICP。 一个集成电路，长期植入温度和压力 遥测单元，将满足这些标准的建议。功率和 数据遥测将安装在皮下颅骨螺栓上， 压力传感器安装在底部或脑实质内探头上。 体外试验后，硬膜外、硬膜下和脑实质内 传感器将被植入四只动物体内。遥测输出将 与标准读数比较3个月，以评估稳定性， 哺乳动物大脑的准确性。 遥测ICP的潜在候选者包括头部 创伤、脑肿瘤、假性脑瘤、脑内和蛛网膜下腔 出血、脑积水、神经外科术后脑肿胀、Reye氏病 综合征、脑感染和毒性/代谢性脑病。 门诊使用可能包括检测患者的脑肿胀 正在接受肿瘤放射治疗，或从头部创伤中恢复 和监测脑积水 第二阶段将侧重于长期测试，制造问题， 临床试验，并结合额外的传感模式。 拟议的商业应用： 如果成功，拟议的遥测仪将提供一个安全，准确， 用于颅内压读数的廉价、可靠、小型装置 和温度它将被用于紧急和重症监护 监测颅内压的情况下，头部创伤和许多 其他条件。遥测仪也可以作为长期 用于脑积水或其他慢性疾病家庭监测的可植入装置 可能导致颅内压过高的情况。

In treatment of brain swelling, cerebral perfusion pressure (CPP) is a critical parameter defined as the difference between mean arterial blood pressure and intracranial pressure (ICP). While mean arterial blood pressure can be routinely monitored, a safe, accurate, inexpensive, reliable, small, implantable pressure telemetry unit is needed to routinely monitor ICP. An integrated circuit, chronically implantable temperature and pressure telemetry unit that will satisfy these criteria is proposed. Power and data telemetry will be mounted on a subcutaneous cranial bolt with a pressure sensor mounted on the bottom or on an intraparenchymal probe. Following in-vitro testing, epidural, subdural and intraparenchymal sensors will be implanted in four animals. Telemetered outputs will be compared with standard readings for 3 months to assess stability and accuracy in mammalian brain. Potential candidates for telemetered ICP include patients with head trauma, brain tumor, pseudotumor cerebri, intracerebral and subarachnoid hemorrhage, hydrocephalus, neurosurgical postop brain swelling, Reye's syndrome, brain infections and toxic/metabolic encephalopathies. Outpatient uses may include detection of brain swelling in patients undergoing radiation therapy for tumors, or recovering from head trauma and monitoring hydrocephalus. Phase II will focus on longer term testing, manufacturing issues, clinical trials, and incorporation of additional sensing modalities. PROPOSED COMMERCIAL APPLICATIONS: If successful, the proposed telemeters will provide a safe, accurate, inexpensive, reliable, small device for readout of intracranial pressure and temperature. It will be marketed for emergency and intensive care monitoring of intracranial pressure in cases of head trauma and many other conditions. The telemeters may also be marketed as a chronically implantable device for home monitoring for hydrocephalus or other chronic conditions that may result in excessive intracranial pressure.