NONINVASIVE PHOTOACOUSTIC INTRACRANIAL PRESSURE MONITOR

本研究旨在开发一种新型的光声传感器， 无创连续监测颅内压（ICP） 头部或脑部受伤的患者。该技术可以测量颅内压 精度变化优于0.5 mmHg，提供了重要的 用于诊断、临床评估和 在急诊现场、医院和家中护理患者。颅内压监测 通过高分辨率（15 μ M）检测位移实现 蛛网膜下腔的血管层， 光声信号的渡越时间。这个信号是由 组织的热应力通过吸收伪随机 调制（PRM）近红外照明。该传感器采用SESI的 专有的PRM和分辨率增强技术， 分辨率和连续测量，而不使组织受到 辐射损伤在第一阶段的可行性研究之后， 脑组织和血管模型，一个坚固耐用的便携式原型 将在第二阶段进行临床试验， 医学研究小组该传感器将与其他传感器集成在一起。 用于检测局部ICP升高的非侵入性诊断技术， 脑血肿或水肿。 拟定商业应用： 该传感器的商业应用非常有前景。它可以用 在急诊现场、急诊室、重症监护室、生理 研究和临床患者管理，用于ICP监测、血液 血氧测定和脑诊断。

This proposal is to develop a novel photoacoustic sensor for the noninvasive and continuous monitoring of the intracranial pressure (ICP) of patients with head or brain injury. The technique can measure the ICP changes to an accuracy of better than 0.5 mmHg, providing an important cerebral physiological parameter for diagnosis, clinical assessment and care of patient at emergency site, hospital and home. ICP monitoring is achieved through the high resolution (15 microM) detection of the shift of the blood vessel layer in the subarachnoid space by measuring the transit time of the photoacoustic signal. This signal is generated by the thermal stress of tissue through the absorption of a pseudo-random modulated (PRM) near IR illumination. The sensor employs SESI's proprietary PRM and resolution enhancement technique to achieve high resolution and continuous measurement without subjecting the tissue to radiation damage. Following the feasibility study in Phase I using a brain tissue and blood vessel phantom, a rugged and portable prototype will be developed in Phase II for clinical test in collaboration with a medical research group. The sensor will be integrated with other noninvasive diagnostic techniques for detection of local ICP elevation, brain hematoma or edema. PROPOSED COMMERCIAL APPLICATION: Commercial applications for the sensor is very promising. It can be used at emergency site, emergency unit, intensive care unit, physiological studies, and clinical patient management for ICP monitoring, blood oximetry and cerebral diagnosis.