Links between DNA replication and chromosome end maintenance

该项目旨在增加对细胞维持其基因组的方式的了解，包括染色体的末端，以使它们能够生存。染色体的末端（端粒）对大多数生物体细胞的生存和增殖至关重要。该项目旨在确定最近发现的端粒维持和细胞维持其基因组完整性之间的联系的分子细节。这可能会增加对基因组维持的基本生物学过程的理解，代表着重大的科学进步。该项目预计将对需要细胞存活的生物技术应用产生深远的影响。

This project aims to increase knowledge of the way in which cells maintain their genomes, including the ends of their chromosomes, to enable their own survival. The ends of chromosomes (telomeres) are essential for survival and proliferation of the cells of most organisms. This project aims to determine the molecular details of a recently discovered link between telomere maintenance and the way cells maintain the integrity of their genome. This is likely to lead to increased understanding of the fundamental biological process of genome maintenance, representing a significant scientific advance. The project expects to have far-reaching implications for biotechnology applications that require the survival of cells.