FIBRIN COMPOSITES FOR GAPING CUTANEOUS WOUNDS

描述：（改编自申请人的摘要）： 富含细胞外基质物质的纤维蛋白凝块 因子对于将细胞募集到伤口部位是重要的。 的目的 第一阶段的建议是开发一种具有止血功能的纤维蛋白， 在一个实施方案中，本发明提供了一种促进细胞募集到损伤部位的复合物。 这 材料在临床环境中将是有用的，其中最佳的 需要止血和快速形成新组织， 急性伤口和清除慢性皮肤溃疡。 申请人 组织设计了一种新型纤维蛋白基质复合材料， 增强细胞募集。 细胞迁移的体外测定 将使用三维细胞外基质边界， 进一步定义和表征该细胞的基本成分 招聘材料 拟议商业应用：不可用

DESCRIPTION: (Adapted from the Applicant's Abstract): The formation of a fibrin clot enriched with extracellular matrix material and growth factors is important for recruiting cells to a wound site. The aim of this phase 1 proposal is to develop a hemostatically functional fibrin composite that facilitates cell recruitment to a site of injury. This material would be useful in clinical settings in which both optimal hemostasis and rapid formation of new tissue are needed, including both acute wounds and debrided chronic cutaneous ulcers. The applicant organization has designed a novel fibrin matrix composite that markedly enhances cell recruitment. An in vitro assay for cell migration across three-dimensional extracellular matrix boundaries will be used in order to define and characterize further the essential components of this cell recruitment material. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE