NEUROCHEMISTRY OF GESTATION-PRODUCED ANALGESIA

描述(改编自摘要)： 拟议的研究是为了检验这样一种假设，即 妊娠和激素模拟妊娠(HSP)是由一种 脊髓kappa和Delta阿片系统之间的乘性相互作用和 在这些系统和去甲肾上腺素能下行通路之间。具体的 目的是(1)确定妊娠和过敏性紫杉醇的止痛作用 由多个独立的脊髓止痛系统组成 或者它是否需要同时激活它们；(2)确定 妊娠和过敏性紫杉醇的抗伤害性作用部分是通过增加脊髓面积来实现的 Kappa和Delta受体密度和/或分布；(3)确定 增强脊髓去甲肾上腺素能张力对于一种重要成分是必要的 如果这种影响是由下腹下丘脑介导的 神经；以及(4)确定新发现的脊髓ORL1/伤害性肽 低效止痛系统调节妊娠和过敏性紫杉醇的镇痛。总而言之， 这项研究应该阐明内在的成分 在怀孕期间被激活的止痛系统，可以提供 孕期疼痛管理干预措施的制定基础 分娩。

DESCRIPTION (adapted from the Abstract): The underlying objective of the proposed research is to test the hypothesis that the antinociception of pregnancy and hormonally-simulated pregnancy (HSP) is mediated by a multiplicative interaction between spinal kappa and delta opioid systems and between these systems and descending noradrenergic pathways. The specific objectives are to (1) determine if the analgesia of pregnancy and HSP consists of the sum of separate, independent spinal cord analgesic systems or if it requires their concomitant activation; (2) determine if the antinociception of pregnancy and HSP is mediated in part by increased spinal kappa and delta receptor density and/or distribution; (3) determine if enhanced spinal noradrenergic tone is necessary for a substantial component of pregnancy analgesia and if this influence is mediated by the hypogastric nerve; and (4) determine if the newly-discovered spinal ORL1/nociceptin hypoanalgesic system modulates analgesia of pregnancy and HSP. All-in-all, this research should elucidate the component of the intrinsic pain-attenuating system that is activated during gestation and could provide a basis developing interventions for the management of pain in pregnancy and childbirth.