MINORITY BIOMEDICAL RESEARCH SUPPORT

该计划的目标是促进和支持生物医学 田纳西州立大学的研究，并鼓励、指导和培训 少数民族学生将成为生物医学研究人员。该程序包含 7个次级项目和2个项目，由协理调查员负责。这 该计划计划支持15名教职员工和18名学生在 细胞生物学和少数民族人口的健康问题。 所进行的研究主要集中在两大令人关注的领域：(1) 调节的分子和细胞机制以及(2)健康问题 在少数族裔人群中。第一个领域将包括如下研究：(1) 药物与DNA结合寻找更好化疗药物的研究 试剂[陈]；(2)金属等环境影响的研究 污染物对棘阿米巴的污染，棘阿米巴是一种投机的人类病原体[汤姆林森]； (3)电磁场和紫外线辐射对哺乳动物的影响 细胞[Alexander-Caudle和Myles]；(4)GABA介导的心脏调节 [纽柯克、布莱克希尔和华盛顿]；(5)系统发育和 酵母杀伤因子的表型变异[甘特]。第二组 的项目关注少数群体的健康问题，包括 (1)二手烟对儿童和青少年的影响[John和 PARKS]；(2)艾滋病教育和干预项目对高校的价值 新生[侯赛尼]；(3)在少数族裔中使用艾滋病预防方案 妇女[林恩和布朗]；和(4)开发一种识别 并消融致心律失常的灶[Ollapally]。 这些研究旨在更好地了解细胞和 生物体调节各种功能的分子事件。此外， 解决了与健康有关的主要问题和条件 在美国人口中的重要性，尤其与 少数族裔。本课程强调台大教职员工的相关研究 为本科生和 研究生。

The objectives of this program are to promote and support biomedical research at Tennessee State University and to encourage, direct and train minority students to become biomedical researchers. The program contains seven subprojects and two projects by associate investigators. This program proposes to support 15 faculty and 18 students to do research in cellular biology and in health problems in minority populations. The research undertaken focuses on two broad areas of concern: (1) molecular and cellular mechanisms of regulation and (2) health problems in minority populations. The first area will include studies such as (1) Study of drug binding to DNA in an effort to find better chemotherapeutic agents [Chen]; (2) Study of the effects of metals and other environmental pollutants on Acanthamoeba, an opportunistic human pathogen [Tomlinson]; (3) The effect os electromagnetic fields and UV radiation on mammalian cells [Alexander-Caudle and Myles]; (4) GABA mediated cardioregulation in Limulus [Newkirk, Blackshear and Washington]; (5) Phylogenetic and phenotypic variation in yeast killer factor [Ganter]. The second group of projects are concerned with health issues among minorities and include (1)Effects of passive smoke on children and young people [John and Parks]; (2) Value of AIDS education and intervention program to college freshman [Husaini]; (3) Use of an AIDS prevention program with minority women [Linn and Brown]; and (4) Development of a technique to identify and ablate arrhythmogenic foci [Ollapally]. These studies are designed to gain a better understanding of cellular and molecular events by which organisms regulate various functions. Further, problems and conditions on health are addressed which are of major importance in the U.S. population, and of particular relevance among minorities. This program emphasizes relevant research by TSU faculty and provides in depth training experiences for both undergraduate and graduate students.