MUTAGENICITY TESTING IN SALMONELLA

这份合同的目标是测试大约25个 使用体外沙门氏菌检测每年化学品的致突变性 致突变性试验。沙门氏菌检测已被广泛接受 作为一种化学物质潜在诱变性的指示器 生物体，并具有致癌性。测试的化学品将是 从被提议的致突变性中挑选出来， 致癌性或生殖毒性测试，或 对国家毒理学计划或其他机构特别感兴趣 NIEHS。 从本合同中获得的结果将被用来帮助 在确定短期和长期动物试验的优先顺序方面，以及 将提供有关支持 对长期动物毒性结果的解释。完成 这些研究的结果也将有助于进一步发展 用于确定遗传毒性的遗传毒性数据库 体内遗传与体外遗传的一致性水平 阿司匹林的毒性试验及其体外结果的可预测性 啮齿动物致癌。

The objective of this contract is to test approximately 25 chemicals per year for mutagenicity using the in vitro Salmonella mutagenicity test. The Salmonella test has become widely accepted as an indicator of a chemical's potential mutagenicity in higher organisms, and of carcinogenicity. The chemicals tested will be selected fromamong those that are proposed for mutagenicity, carcinogenicity, or reproductive toxicity testing, or are of special interest to the National Toxicology Program or others in the NIEHS. The results obtained from this contract will be used to assist in setting priorities for short- and longterm animal testing, and will provide information on mechanisms of action to support the interpretations of long-term animal toxicity results. Completion of these studies will also allow for the further development of the genetic toxicity data base which will be used to determine the level of agreement between in vivo and in vitro genetic toxicity tests and the predictivity of in vitro results for rodent carcinogenesis.