NEUROSCIENCES AND BIOINFORMATICS AT HUNTER COLLEGE

亨特学院基因结构与功能研究中心 将继续致力于开展高质量的研究， 招募少数族裔科学家和博士候选人对此 企业. 亨特可以为这个国家做出特殊的贡献 事业。 我们不断改进我们的研究活动; 我们的实验室是国际公认的。我们的学生团体是 非常多样化，反映了纽约的种族和民族多样性 城市本身。 我们最近聘请了更多的少数民族教师，并希望 继续这个。我们的要求包括在学校雇用新教师的资金。 直接费用预算与建设的机构承诺 他们的实验室。 还要求为少数群体研究提供资金 帮助我们的研究工作并使我们的员工多样化的同事。一个主要 我们建议的重点是减少对RCMI资金的依赖 随着时间 因此，为教职员工和 核心设施的管理人员的结构，使他们的支持， RCMI的预算将在赠款的后期逐步取消。 在这 框架内，不同时期要求全职工资 时间，为生物分子计算和图形的管理人员 设施、生物成像设施和质谱设施。 最后两个是特别合理的新的研究倡议的 生物系和化学系。 生物心理学研究 还介绍了倡议。 研究倡议集体 定义教师招聘的领域，并提供如何 核心设施提供基本服务。 我们申请资金 为这些服务提供技术支持，这些服务将在赠款期间逐步取消 期这些设施所需用品的申请每年 减少金额。 这一新提案对以下方面提出了一些主要要求： 仪器仪表 预算的结构是为了使当前和未来 明确界定了机构的贡献。 我们继续看到 RCMI计划之外的新支持来源。新的艾滋病毒和艾滋病- 介绍了相关项目。 这包括三个方面： 合成和作用机制研究，激活和控制 从HIV LTR的转录，以及可能的应激效应， 艾滋病痴呆的生理学 化学研究计划也有 临床意义的艾滋病毒/艾滋病的研究喷他脒， 癌症研究（丝裂霉素C的衍生物）。

The Center for Study of Gene Structure and Function at Hunter College will continue to focus on conducting research of high quality and recruiting minority scientists and Ph.D. candidates into this enterprise. Hunter can make a special contribution to this National undertaking. We have steadily improved our research activities; some of our laboratories are internationally recognized. Our student body is remarkably diverse, reflecting the racial and ethnic variety of New York City itself. We have recently hired more minority faculty and wish to continue this. Our request includes funds for hiring new faculty in the direct costs budget with an institutional commitment to the construction of their laboratories. Also requested are funds for minority research associates who help our research effort and diversify our staff. A major emphasis in our proposal is to reduce our dependence on RCMI funding over time. Therefore, funding of the positions for faculty and managers of core facilities is structured so that their support from the RCMI budget will be phased out in the later years of the grant. In this framework, full time salaries are requested, for different periods of time, for managers of the Biomolecular Computation and Graphics Facility, the Bio-imaging Facility, and the Mass Spectroscopy Facility. The last two are specially justified in new Research Initiatives of the Departments of Biology and Chemistry. A Biopsychology Research Initiative is also described. The Research Initiatives collectively define areas for faculty recruitment, as well as provide examples of how core facilities supply essential services. We request funds for technical support for these services which are phased out over the grant period. Supplies for these facilities are requested, in annually decreasing amounts. This new proposal contains few major requests for instrumentation. The budget is structured so that current and future institutional contributions are clearly delineated. We continue to see new sources of support outside of the RCMI program. New HIV and AIDS- related projects are presented. These comprise three areas: drug synthesis and mechanism-of-action studies, activation and control of transcription from the HIV LTR, and possible stress effects in the physiology of AIDS dementia. The Chemistry Research Initiative also has clinical - significance for HIV/AIDS in studies of pentamidine, and for cancer research (derivatives of Mitomycin C).