POPULATION GENETICS OF INTERACTIONS

我们的长期目标是提供一个统一的进化理论 相互作用建立在种群遗传学的原则上。五个项目 都是与这一总目标有关的。首先，我建议研究 信息错误在性行为起源和进化中的作用 周而复始。这个项目研究的是交替的起源和演变。 世代，这是真核生物生命周期的基础。第二，我 建议研究有害突变在人类免疫缺陷病毒的进化中的作用 生殖系统。第三，我建议研究变异在 适合性在沟通的演变中。最近，几个假说 已经提出了关于适合度变化在配偶选择中的作用 该项目力求为评价 这项工作。第四，我建议研究近亲交配对 社会行为的演变及社会行为对人的影响 近亲交配的进化。第五，我建议研究体细胞的进化。 大脑中神经元之间相互作用的时间。通过将两者结合起来 进化和神经生物学的行为方法，拟议的工作 从终极或终极的角度来研究适应行为 进化因果关系和神经元的近似性观点 机械装置。 拟议的工作之所以重要，原因如下。问题所在 地址，性重组，动物交流，繁殖系统， 社交行为和大脑中的类别形成都是主要的 生物学中尚未解决的问题。大多数人类疾病、病原体和寄生虫 是在社交互动中传播的。拟议的工作研究了 这些相互作用对个体生物适合性的影响 以及这些影响是如何演变的。

Our long term objective is to provide a unified theory of the evolution of interactions built on the principles of population genetics. Five projects are proposed relating to this general goal. First, I propose studying the role of informational error in the origin and evolution of the sexual cycle. This project addresses the origin and evolution of alternation of generations, which is basic to the life cycle of eukaryotes. Second, I propose studying the role of deleterious mutation in the evolution of reproductive systems. Third, I propose studying the role of variation in fitness in the evolution of communication. Recently, several hypotheses have been advanced concerning the role of fitness variation in mate choice and this project seeks to provide a common framework for the evaluation of this work. Fourth, I propose studying the effect of inbreeding on the evolution of social behavior and the effect of social behavior on the evolution of inbreeding. Fifth, I propose studying the evolution in somatic time of interactions between neurons in the brain. By combining both the evolutionary and neurobiological approaches to behavior, the proposed work studies adaptive behavior both from the point of view of ultimate or evolutionary causality and from the proximate point of view of neuronal mechanisms. The proposed work is important for the following reasons. The problems addressed, sexual recombination, animal communication, breeding system, social behavior, and category formation in the brain, are all major unsolved problems in biology. Most human diseases, pathogens and parasites are transmitted during social interactions. The proposed work studies the effects of these interactions on the biological fitnesses of individuals and how these effects have evolved.