NATRIURETIC PEPTIDES AND THE LUNG

描述(根据申请者的抽象和具体目标改编)： 自1981年发现利钠肽以来，大量的 研究已经表征了分子生物学、药理学和 这一家族多肽的生理学意义。目前，3 已知存在主要的NPs；心房(ANP)、脑(BNP)和C型 利钠肽(CNP)。三个NP受体也已经被 其特征是，A和B受体与颗粒物有关 鸟苷环化酶，以及被认为主要服务于 清除功能。这些多肽被认为在血液中起作用 压力和液体动态平衡。近年来，有相当多的证据表明 也支持心钠素在心绞痛中起生理作用的假设 心钠素对肺血管张力和重塑的调节作用。这 该项目旨在进一步调查世界银行的作用和行动机制 NPS及其受体在肺血管张力调节中的作用 改建。具体目标是：1)评估生理学 NPs在调节慢性肺动脉高压中的意义 评价促进CNP合成和释放的机制 CNP在肺血管系统中的潜在生理作用； 研究NP受体的数量、分布和循环的调节 在肺里。

DESCRIPTION (Adapted from applicant's abstract and specific aims): Since the discovery of natriuretic peptides in 1981, a tremendous amount of research has characterized the molecular biology, pharmacology, and physiologic significance of this family of peptides. At the present time, 3 main NPs are known to exist; atrial (ANP), brain (BNP) and C-type natriuretic peptides (CNP). Three NP receptors have also been characterized, the A and B receptors that are linked to particulate guanylate cyclase, and the C-receptor that is thought to serve mainly a clearance function. The peptides are thought to play a role in blood pressure and fluid homeostasis. In recent years, considerable evidence has also accrued to support the hypothesis that ANP plays a physiologic role in the regulation of pulmonary vascular tone and remodeling by ANP. This project aims to further investigate the role and mechanisms of action of the NPs and their receptors in the regulation of pulmonary vascular tone and remodeling. The specific aims are to: 1) assess the physiologic significance of NPs in modulating chronic pulmonary hypertension; 2) evaluate the mechanisms contributing to the synthesis and release of CNP and the potential physiologic role of CNP in the pulmonary vasculature; and 3) investigate regulation of NP receptor quantity, distribution, and recycling in the lungs.