CORE--GENETICALLY MODIFIED MICE

转基因小鼠共享服务为 癌症中心和其他大学的研究人员获得转基因动物 技术，以节省成本的方式。这个核心允许 研究人员使用转基因小鼠，从1997年11月开始， 服务将能够协助研究人员生产新的鼠标 突变体的胚胎干细胞（ES细胞）的基因靶向。该服务还 将为胚胎干细胞研究提供基因打靶技术。期间 在过去的一年半里，通过汇编信息， 在其他可用的分子改变的小鼠身上。共享服务 工作人员协助获得小鼠并对其进行维护和筛选。 其目标是帮助调查人员识别或开发模型，以解决 他们的癌症研究自从开发或建立殖民地以来 这些特殊的鼠标是非常昂贵的，共享服务集中 这些努力，从而减少了一些大的启动成本， 当开发动物模型时。重要的是，该设施允许 以前没有使用过小鼠模型的人将被引导 在他们的使用。随着越来越多的研究人员意识到 在这些系统中，使用这项服务的人数每年都在增加， 存在的前三年。

The Genetically Modified Mice Shared Service provides members of the Cancer Center and other University researchers access to transgenic animal technology in a n efficient cost-saving manner. This core allows investigators to use transgenic mice and, beginning in November 1997, the service will be able to assist investigators in producing new mouse mutants by gene targeting in embryonic stem (ES) cells. The service also will provide gene targeting technology for ES cell research. During the last year and a half, services have been expanded by compiling information on other molecularly altered mice that are available. The shared service personnel assist in obtaining the mice and maintaining and screening them. The goal is to help investigators identify or develop models to address their specific cancer research. Since developing or establishing colonies of these special mice is very expensive, the shared service centralizes these efforts, thus reducing some of the large start-up costs that occur when developing animal models. Importantly, this facility allows individuals who have not previously worked with mouse models to be guided in their use. As more investigators have come to realize the power of these systems, use of this service has increased each year, during the first three years of existence.