MECHANISMS OF INTERCELLULAR CALCIUM WAVES

描述：细胞间钙波的机制将是 在上皮细胞和神经胶质细胞培养物以及海马中进行了研究 外植体培养。 在多种细胞中观察到胞间Ca波 类型：它们协调上皮细胞中的纤毛活动，也是 涉及伤口愈合、细胞生长和 分化和机械转导。 因为细胞间Ca波 也被观察到从神经胶质细胞传递到神经元，它们也可能 在信息处理中发挥作用。 数学模型将用于 研究细胞间Ca波。 初步工作将检查细胞内 振荡和波，形成细胞间波的基础。 在 根据最近的信息，以前用于模拟波浪的假设 传播将被修改并应用于神经胶质细胞中的研究波 cultures. 最后，该模型将用于确定 细胞内波可以在更大的空间尺度上耦合， 具有高度组织性的细胞间波，例如传播的 平面波前和旋转螺旋。

DESCRIPTION: The mechanisms underlying intercellular calcium waves will be investigated in epithelial and glial cell cultures and in hippocampal explant cultures. Intercellular Ca waves are observed in a variety of cell types: they coordinate ciliary activity in epithelial cells, and are also implicated in early stages of wound healing, cell growth and differentiation, and mechanotransduction. Because intercellular Ca waves have also been observed passing from glial cells to neurons, they may also play a role in information processing. Mathematical models will be used to study intercellular Ca waves. Initial work will examine intracellular oscillation and waves, which form the basis of intercellular waves. In the light of recent information, assumptions previously used in modelling wave propagation will be modified and applied to the study waves in glial cell cultures. Finally, the model will be used to determine mechanisms by which intracellular waves can be coupled on a larger spatial scale to form intercellular waves with a high degree of organization, e.g. propagating plane wave fronts and rotating spirals.