CLINICAL PANCREATIC ISLET TRANSPLANTATION

我们将进行总共20个同时进行的肾胰岛移植。 的 第一组将胰岛置于肾包膜下， 第二组将通过肝内注射胰岛， 门静脉 接受者将是肾衰竭患者， 1型糖尿病 我们的研究将有助于确定最佳候选人， 胰岛免疫抑制、部位和可行性 移植 在移植前，c肽阴性将是 使用胰高血糖素激发进行验证。 1周、1个月、3个月、6个月时 月和1-5年每年评估胰岛素分泌 使用sustacal膳食挑战测试。

We will perform a total of 20 simultaneous kidney-islet transplants. The first group will have the islets placed under the kidney capsule, the second group will have the islets injected intrahepatically via the portal vein. The recipients will be patients who kidney failure and have type 1 diabetes. Our research will help define the optimal candidates, immunosuppression, site, and feasibility of pancreatic islet transplantation. Prior to transplantation, c-peptide negativity will be verified using a glucagon challenge. At 1 week, 1 month, 3 months, 6 months, and yearly from 1-5 years, insulin secretion will be assessed using a sustacal meal challenge test.