eScent mask for personal protective assurance: a human-centred approach to PPE in the post COVID-19 world

冠状病毒引发的恐慌导致全球对口罩的需求。与新冠肺炎相关的创伤已导致许多医护人员死亡。最近发表在《细胞》[1]上的研究表明，SARS-CoV-2感染呼吸道细胞，鼻部是肺部感染的主要部位。这为未来的鼻腔可穿戴治疗策略开辟了新的方向，可以减少新冠肺炎和其他冠状病毒在鼻子中的传播。应对疫情的挑战需要学科之间富有想象力的合作，并可能受益于一项提高人们情绪和心理健康的创新。eScent正在可穿戴式、可持续的声控香水分配领域设计一种新的运动。与IF/Anchored-In合作，我们正在将一种产品商业化，该产品寻求通过舒缓的芳香氛围来增强免疫系统，同时改善FFP3口罩提供的当前保护。该项目的目标是将目前的eScent分配器(TR3)带到相关环境(TR6)的增强型口罩演示器，以便它发出安全有效的气味，同时阻止SAR受体，作为一线工作人员PPE的新解决方案。eScent是一种可穿戴的微升剂量递送设备，通过传感器/应用程序/语音识别软件分配任何液体。它建立在20年来传感器诱导的气味释放技术和纺织品研究(中央圣马丁/剑桥大学)、与飞利浦、North Face的项目以及谷歌和TransTech实验室的支持的基础上。在5项专利的保护下，eScent结合了感知人类情感和分配对抗活动的健康气味来提高生活质量。我们干预的心理影响应该从根本上减少医疗保健、运输和急救人员的创伤。我们进入市场的途径是通过Gentex Europe(NHS/军用个人防护用品供应商)，NIHR Brain MIC和剑桥大学临床学院表示有兴趣，作为减轻危机心理影响的一种新方法。尽管我们的想法不是立竿见影的解决方案，但它与未来的冠状病毒爆发高度相关。如果有效的疫苗需要比预期更长的时间，那么它对当前的大流行也是有效的。自动售货机将从护士/接待员/公交车司机或军人佩戴的口罩/面罩内提供经美容批准的液体(带有皮肤/眼睛的安全数据)，作为威慑/预防“云”，以遏制病毒的传播和减少创伤。我们的技术建立并维护了一个可检测到气味(和其他喷雾)的局部“球体”，取决于用户环境和/或声敏可穿戴液体自动售货机分配的环境。未来的迭代将使用面具数据，ML技术来个性化治疗和护理，这样一旦人工智能系统检测到压力增加(使用语音分析)或环境变化，就可以提供基于证据的抗病毒药物/芳香。气味传递是由智能手表中磨损的生物传感器的生命体征(例如温度、心率变异、语音特征/命令、位置、医院/商店、公共交通中的上下文数据)触发的，并包含在由可生物堆肥/可再填充胶囊组成的“消耗品”中(循环经济)。没有口罩可以实时分配化合物以防止新冠肺炎\.\[1\].Hou等，_SARS-CoV-2反向遗传学揭示了呼吸道中一种可变的感染梯度，细胞182，1-18,2020年7月

The panic around coronavirus has resulted in global demand for masks.The trauma associated with COVID-19 has led to the deaths of many healthcare staff. Recent research published in Cell \[1\] suggests that SARs-CoV-2 infects cells of the respiratory tract with the nose being the dominant site from which lung infections begin. This opens new directions for future intranasal wearable therapeutic strategies that could reduce transmission of COVID-19 and other coronaviruses in the nose.The challenge of the pandemic requires imaginative collaborations between disciplines and could benefit from an innovation that enhances the emotional and mental wellbeing of the population.eScent is engineering a new movement in wearable, sustainable voice-activated scent dispensing. In partnership with IF/Anchored-IN, we are commercializing a product that seeks to calm people with a soothing aromatic atmosphere to boost the immune system, whilst improving on current protection provided by FFP3 masks.The aim of this project is to take the current eScent dispenser (TR3) to an enhanced- mask demonstrator in relevant environments (TR6) so that it emits a safe and effective aroma whilst blocking SAR receptors as a novel answer to PPE for frontline workers.eScent is a wearable pico-litre dosed delivery device that dispenses any liquid via sensors/app/voice-recognition software. It builds on 20 years of sensor-induced scent-release technology and textile research (Central Saint Martins/Cambridge University), projects with Philips, North Face, and support from Google, TransTech Labs. Protected by 5 patents, eScent unites sensing human emotion and dispensing counter-active wellbeing aromas to improve quality of life.The psychological effect of our intervention should radically reduce the trauma of healthcare, transport, and emergency workers. Our route to market is via GENTEX Europe (NHS/Military PPE supplier), with interest expressed by the NIHR Brain MIC, and University of Cambridge Clinical School as a novel way to mitigate the psychological impact of the crisis. Although our idea is not an immediate solution, it is highly relevant for future coronavirus outbreaks. If an effective vaccine takes longer than expected, it is also valid for the current pandemic. The dispenser would deliver a cosmetically approved liquid (with safety data for skin/eyes) from inside a facemask/visor that nurses/receptionists/bus drivers or military wear as a deterrent/prevention "cloud" to curb the spread of viruses and reduce trauma.Our technology establishes and maintains a localized "sphere" of detectible levels of scent (and other sprays) dependent upon user-context and/or the environment dispensed from a voice-sensitive wearable liquid dispenser. Future iterations will use mask data, ML technology to personalize treatment and care such that evidenced-based antivirals/aromas can be delivered once an AI system has detected an increase in stress (using voice analytics) or environmental changes. Scent delivery is triggered by vital signs from worn biometric sensors in a smartwatch (e.g. temperature, HRV, speech characteristics/commands, location, contextual data in hospitals/shops, public transport) and contained in "consumables" consisting of bio-compostable/refillable capsules (circular economy).There is no mask that dispenses compounds in real-time to prevent COVID-19\.\[1\].Hou et al.,_SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract_,Cell 182,1--18,July,2020