SEQUENTIAL KIDNEY/PANCREATIC ISLET CELL TRANSPLANTATION

我们将进行20例序贯肾胰岛移植。这个 胰岛将通过门静脉经皮注入肝脏。 受赠者将是肾脏功能稳定且 患有1型糖尿病。我们的研究将有助于确定最优 胰岛的候选、免疫抑制、部位和可行性 移植。在移植前，C肽阴性将是 用胰高血糖素进行了验证。1周、1个月、3个月、6个月 每月，每年1-5年，将对胰岛素分泌进行评估 使用的是餐饮挑战测试。

We will perform a total of 20 sequential kidney islet transplants. The islets will be injected percutaneously into the liver via the portal vein. The recipients will be patients who have a stable functioning kidney and have type 1 diabetes. Our research will help define the optimal candidates, immunosuppression, site, and feasibility of pancreatic islet transplantation. Prior to transplantation, C-peptide negativity will be verified using a glucagon challenge. At 1 week, 1 month, 3 months, 6 months, and yearly from 1-5 years, insulin secretion will be assessed using a sustacal meal challenge test.