DROSOPHILA MISGUIDED GENE AND TRACHEAL CHEMOTAXIS

这项研究的长期目标是了解分子 植物枝条末端生长过程中趋化性的调控机制 果蝇的气管系统。这些细胞的定向生长是 由来自缺氧的吸引人的引导信号控制 目标组织。这类似于其他上皮细胞的发育 管子，如哺乳动物的血管系统，其中的毛细血管也 根据其目标组织的氧气需求而发展。 因此，基因的分子特征被误导了，这已经 错路的末端分支，以及其他基因的鉴定 影响这些细胞的定向生长将有助于阐明 控制末端细胞生长的分子机制。在漫长的岁月里 术语，这种类型的分子遗传学方法有望识别 起源于气管信号的靶问题，导致更大的 了解氧在调节这些信号中的作用，决定 将这些信号传递给 终末细胞，并阐明了在 顶枝的胞质突起。研究如何将 靶组织的生理需求与 果蝇的终末细胞的发育也将导致 在其他较少的系统中对这个过程的分子理解 服从分子遗传学的。

The long term objective of this research is to understand the molecular mechanisms regulating chemotaxis during terminal branch outgrowth in the tracheal system of Drosophila. The directed outgrowth of these cells is controlled by an attractive guidance signal originating from oxygen-starved target tissues. This is similar to the development of other epithelial tubes, such as the mammalian vascular system, in which the capillaries also develop in response to the oxygen needs of their target tissues. Therefore, the molecular characterization of the gene misguided, which has misrouted terminal branches, as well as the identification of other genes affecting the directed outgrowth of these cells will help elucidate the molecular mechanisms controlling terminal cell outgrowth. In the long term, this type of molecular genetic approach will hopefully identify the tracheogenic signals originating from the target issues, lead to a greater understanding of the role of oxygen in regulating these signals, determine the manner in which these signals are communicated to and transduced by the terminal cells, and elucidate the cellular mechanisms used during cytoplasmic outgrowth of the terminal branches. Studying how the physiological requirements of the target tissues are coupled to the development of the terminal cells in Drosophila will also lead to a molecular understanding of this process in other systems that are less amenable to molecular genetics.