PREVENTION AND TREATMENT OF IMPOTENCE

这是一个竞争性的更新应用程序，其中作者有 发现生长激素显著促进了 海绵体神经损伤后的一氧化氮合酶神经 一群年轻的老鼠 作者建议检查和比较 青年和老年大鼠对海绵体神经损伤的反应 研究生长激素及其介导的胰岛素样物质对 生长因子系统对勃起机制的影响。 如果证明有益 在拟议的实验中，临床应用生长激素或 IGF可能成为一种重要的预防和治疗肥料， 神经性阳痿 具体目的是：1.测试 假设海绵体神经损伤对 青年和老年人非肾上腺素能非胆碱能血管舒张系统 大鼠 2：为了检验细胞和分子 与海绵体神经损伤相关的阳痿机制是由于 NOS、TGF、NGF、IGF、FGF和TGF-β基因和蛋白质表达的改变 青年和老年大鼠肾上腺素受体。 3：检验假设， 生长激素促进海绵体神经的再生， 年轻和年老的老鼠4：检验假设， 通过生长促进NANC和副交感神经再生 激素是由于IGF和IGFBBP的产生。

This is a competitive renewal application in which the authors have found that growth hormone significantly facilitated the regeneration of nitric oxide synthase containing nerves after cavernous nerve injury in a group of young rats. The authors propose to examine and compare the response to cavernous nerve injury in a group of both young and old rats and to study the effect of growth hormone and its mediator insulin-like growth factor system on the erectile mechanism. If proved beneficial in the proposed experiments, clinical application of growth hormone or IGF could become an important preventative and therapeutic manure for neurogenic impotence in humans. The specific aims are: 1: To test the hypothesis that injury to the cavernous nerve has different effects on the nonadrenergic noncholinergic vasodilator system in young and old rats. 2: To test the hypothesis that the cellular and molecular mechanisms of impotence associated with cavernous nerve injuries are due to altered gene and protein expression of NOS, TGF, NGF, IGF, FGF and adrenoreceptor in young and old rats. 3: To test the hypothesis that growth hormone facilitates regeneration of the cavernous nerve in both young and old rats. 4: To test hypothesis that the mechanism of facilitated NANC and parasympathetic nerve regeneration by growth hormone is due to production of IGF and IGFBBPs.