ASN CONFERENCE--AGE RELATED NEURODEGENERATION

1999年美国神经化学学会年会将于3月14日至3月17日在新奥尔良举行。组织了一系列研讨会、研讨会和座谈会，主题有两个，与增进对与年龄相关的神经退行性疾病的分子和细胞基础的理解有关。1)细胞和分子信号机制参与适应性神经元可塑性和神经退行性疾病。我们对神经递质、神经营养因子和细胞因子激活的信号级联反应的理解仍然很差。生化和分子解剖这类通路的专家将介绍他们的最新发现，放在他们参与神经退行性疾病的背景下。2)神经细胞凋亡性死亡机制。线粒体改变、氧化应激以及“杀手”基因和蛋白酶的激活的关键作用正在显现。细胞凋亡、氧化应激、线粒体功能和离子稳态调节等领域的专家将提供与各种年龄相关的神经退行性疾病相关的神经元死亡机制的最新分析。此外，ASN会议的第三个主题是探索新兴的分子、生物物理和纳米技术方法的当前和未来应用，以加快我们理解和操纵神经元可塑性和死亡的能力。这将涉及学术界和工业界专家之间的信息交流，他们的工作重点是技术进步和药物发现。这一系列讲座和讲习班的总体目标是交流和整合研究人员在其特定专门领域的前沿领域提供的科学信息。大力吸引和支持研究生和博士后科学家。

The 1999 Annual Meeting of the American Society for Neurochemistry will be held in New Orleans from March 14 - March 17. A series of Symposia, Workshops and Colloquia has been organized with two major themes relevant to improved understanding of the molecular and cellular underpinnings of age-related neurodegenerative disorders. 1) Cellular and molecular signaling mechanisms involved in both adaptive neuronal plasticity and in neurodegenerative disorders. Our understanding of signaling cascades activated by neurotransmitters, neurotrophic factors and cytokines remains poor. Experts in biochemical and molecular dissection of such pathways will present their latest findings, placed in the context of their involvement in neurodegenerative disorders. 2) Mechanisms of apoptotic neuronal death. Critical roles for mitochondrial alterations, oxidative stress and activation of "killer" genes and proteases are emerging. Experts in the areas of apoptosis, oxidative stress, mitochondrial function, and regulation of ion homeostasis will provide up-to-date analyses of mechanisms of neuronal death relevant to various age-related neurodegenerative disorders. In addition, a third theme of the ASN meeting is to explore the current and future applications of emerging molecular, biophysical and nanotechnological approaches to accelerate our ability to understand and manipulate neuronal plasticity and death. This will involve information exchange between experts in academia and industry who focus their efforts on technological advances and drug discovery. The overall objective of this series of lectures and workshops is to establish a cross-fertilization of and integration of scientific information from investigators on the cutting edge of their particular area of expertise. A major effort will be made to attract and support graduate students and postdoctoral scientists.