ESTIMATION OF HIGHEST TASK SILICA EXPOSURES

描述：（改编自研究者摘要）不止一个 每年有100万工人在工作场所接触二氧化硅。 对北卡罗来纳州Dusty Trades数据的初步分析， 二氧化硅暴露影响的安全响应研究资源， 表明最高的任务相关暴露与 发展成硅肺;然而，假设暴露为零， 未抽样任务在该分析。 这项研究的目的是 研究创新的方法来估计二氧化硅暴露在未抽样的任务。 经过更完整的文献回顾，将选择三种方法， 插补缺失最高任务暴露数据。 最初，以下 正在考虑的方法： 商品特定任务，95%置信区间的下限 商品特定任务的中位数和最大似然估计。 最后三种方法的结果将被描述和对比。 最后，将对先前的 确定的病例和对照。 使用以下方法的优势比的任何差异 最高任务暴露度量和累积暴露度量将是 测试. 如果发现最高任务指标（具有插补值）为 有关矽肺的发展，采样方法的变化和有针对性的 今后可以采用控制技术来减少疾病。

DESCRIPTION: (Adapted from the Investigator's Abstract) More than one million workers are exposed annually to silica in the workplace. Preliminary analyses of the North Carolina Dusty Trades data, a unique resource for exposure-response studies of the effects of silica exposure, indicates that the highest task-related exposure is strongly related to the development of silisosis; however, an exposure of zero was assumed for unsampled tasks in that analysis. This study is being conducted to investigate innovative ways to estimate silica exposure in unsampled tasks. After a more complete literature review, three methods will be selected to impute missing highest task exposure data. Initially, the following approaches are being considered: the mean exposure at sampled commodity-specific tasks, the lower bound of the 95% confidence interval of the median of commodity-specific tasks, and a maximum likelihood estimate. The results from the final three methods will be described and contrasted. Finally an exposure-response analysis will be conducted for the previously identified cases and controls. Any differences in the odds ratios using the highest task exposure metric and the cumulative exposure metric will be tested. If the highest task metric, with imputed values, is found to be related to silicosis development, changes in sampling methods and targeted control techniques could be implemented to decrease disease in the future.