EFFECT OF VOLATILE ANESTHETICS ON CA2+ ATPASE

麻醉药在临床上已经使用了近100年，但 它们的作用机制尚不清楚。麻醉药的作用 如醇、巴比妥酸盐对荧光强度衰减的影响 对多色氨酸蛋白PM-ATPase进行了研究。时间分辨率 荧光证实了荧光的扩散特性 淬火。淬火对裸露的表面最有效 色氨酸。关于麻醉药对心脏的影响的信息 膜结合蛋白可能为深入了解 行动。

Anesthetics have been in clinical use for nearly 100 years, but their mechanism of action is still unknown. Effect of anesthetics such as alcohols, barbiturate on fluorescence intensity decay of multitryptophan protein PM ATPase of has been studied. Time-resolved fluorescence confirms the diffusional character of the fluorescence quenching. Quenching is most effective on surface exposed tryptophans. Information on the effects of anesthetics on membrane-bound proteins may provide insights into the mechanism of action.