MAMMARY CARCINOGENESIS IN RATS--HORMONAL PREVENTION

描述：（改编自申请人的描述）第一个完整的术语 在青少年时期怀孕的妇女可以永久地减少他们的 患乳腺癌的风险。 在目前的提案中， 研究者将彻底分析产次相关的原因 对大鼠乳腺癌发展的难治性，并检查 奋乃静的保护作用机制， 会引起短暂的催乳素血症 该提案包括四个具体目标： [1]经产大鼠对MNU诱发乳腺癌的不应性研究 致癌作用，[2]不应性是否是永久性的，[3] 描述奋乃静诱导的耐火性，[4]机制 奋乃静导致的顽固性 长期目标是 来产生一个实验范例， 用于预防人乳腺癌，而不显著改变 生活品质

DESCRIPTION: (Adapted from Applicant's description) First full term pregnancy during the teen age years in women can permanently reduce their risk for developing breast cancer. In the current proposal, the investigator will thoroughly analyze the causes of parity-related refractoriness to mammary cancer development in rats, and examine the mechanism underlying the protection effect of perphenazine, a drug which causes transient prolactinemia. The proposal includes four Specific Aims: [1] Studies of the refractoriness of parous rats to MNU-induced mammary carcinogenesis, [2] whether the refractoriness is permanent, [3] characterize the perphenazine-induced refractoriness, and [4] the mechanism underlying the perphenazine-induced refractoriness. The long-term goal is to generate an experimental paradigm that can be used to develop strategies for the prevention of human breast cancer without significant alterations in the quality of life.